Cytiva US LLC

Pall Corporation

Bojan Isailovic

Michael B Seal

Darren G Elton

Thomas James Hartridge

Robert Flisar

Jens Bretschneider

Jeremy Rautenbach

A buffer management system includes at least one workstation configured to support a supply of concentrated buffer solution and an inline dilution skid having a manifold and at least one workstation to support delivery of diluted (surge) buffers from the inline dilution skid. The latter workstation also serves to supply ready-made (diluted) buffers to a bioprocessing unit. The manifold is in fluid communication with the supply of concentrated buffer solution and is adapted to be placed in fluid communication with a source of water for injection (WFI). The inline dilution skid is configured to variably mix the supply of concentrated buffer solution and the source of WFI to obtain a range of diluted buffer solutions. Processes for automatically identifying the arrangement of buffer solutions in a bioprocessing application use signals from various sensors to identify the fluid connections between components of the system.

Single use manifold for buffer management system

Buffer management and identification in bioprocessing system

A fluid distribution system includes single use distributor manifolds each having a distributor manifold inlet and a plurality of distributor manifold outlets in fluid communication with the distributor manifold inlet. A set of single use filler manifolds can be sequentially connected to a respective one of the outlets of a single use distributor manifold immediately upstream of the connection point of the set of single use filler manifolds. In embodiments, an upstream distributor manifold can be used to feed fluid to a set of intermediary distributor manifolds where the set of intermediary distributor manifolds corresponds to the number of outlets of the upstream distributor manifold.

Fluid distribution system with single use manifold assembly for scaled filling

Fluid distribution system with single use manifold fluid recovery assembly

A mechanically driven agitator for use in bioprocessing, including a seal housing providing an integral seal around the agitator shaft is provided. Additionally, a fluid mixing assembly comprising a container and the agitator, as well as a support assembly for supporting the fluid mixing assembly, the support assembly further comprising a mounting assembly for lockably engaging the seal housing, are also provided.

Mechanical agitator with seal housing assembly

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Portsmouth, United Kingdom

Bojan Isailovic