King Fahd University of Petroleum and Minerals

Boja Poojary

Katharigatta N Venugopala

Vinuta Kamat

Mohamed A Morsy

Pran Kishore Deb

Bandar Aldhubiab

Mahesh Attimarad

Anroop B Nair

Nagaraja Sreeharsha

Rangappa Santosh

Vijay M Kumbar

Manohar S Kugaji

Amit Kumar

Rashmi Venugopala

Compounds for treating a microbial and/or bacterial infection and, particularly, to compounds of formula 4 as identified below that are 5-(substitutedphenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-microbial or anti-bacterial agents, with the substituents defined as stated herein.

5-(substitutedphenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues as antibacterial agents

Compounds for treating a microbial and/or bacterial infection and, particularly, to compounds that are 5-(substituted phenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-microbial or anti-bacterial agents. The compounds having the formula 4:

Compounds for treating an inflammatory disease, disorder, or condition and, particularly, to compounds that are 5-(substitutedphenyl)-7-imino-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-inflammatory agents.

5-(Substitutedphenyl)-7-Imino-7,8-Dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues as anti-inflammatory agents

7-Imino-5-(1H-indol-3-yl)-1,3-substituted-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The present compounds, identified as COX-2 inhibitors, are useful as anti-inflammatory agents.

7-Imino-5-(1H-indol-3-yl)-1,3-substituted-7,8-dihdropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione as anti-inflammatory agents

Compounds for treating cancer and, particularly, to compounds that are 5-(3-substituted phenyl)-pyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,8H)-trione analogues and their use as anticancer agents.

5-(3-substituted phenyl)-pyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,8H)-trione derivatives as anticancer agents

Compounds for treating cancer and, particularly, to compounds that are 5-(3-substituted phenyl)-pyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,8H)-trione analogues and their use as anticancer agents. The compounds have the structure: wherein: Ris selected from the group consisting of hydrogen, hydroxy, and benzyloxy; Ris selected from the group consisting of hydrogen, a C-Cstraight or branched chain alkoxy, and benzyloxy; Ris selected from the group consisting of hydrogen and a C-Cstraight or branched chain alkyl; and Ris selected from the group consisting of hydrogen and a C-Cstraight or branched chain alkyl.

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Mangalagangothri, India

Boja Poojary