Ciba-geigy Corporation

Bohumir Lukas

Karl H Schmidt-Ruppin

Walter Wiesendanger

Gerhard Baschang

Albert Hartmann

Oskar Wacker

Bruno Fechtig

Franz X Fischer

Karl H Ruppin

Elfy Aeschlimann

Described are the use of hexopyranose compounds of the formula I ##STR1## for the prophylaxis and treatment of virus infections, and novel pharmaceutical preparations especially suitable for the use in accordance with the invention. The substituents in formula I have the meanings given in the claims.

Use of sugar derivatives for the prophylaxis and treatment of virus

Described are phosphatidyl compounds of the formula I ##STR1## in which R.sup.1 represents C.sub.3-14 -alkanoyl, benzoyl, the acyl radical of an .alpha.-aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the .alpha.-amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a .beta.-aminocarboxylic acid or an .alpha.- or .beta.-hydroxycarboxylic acid,

Phosphatidyl compounds, processes for their manufacture, and their use

The invention relates to an antiherpetic lipstick which is characterized by a content of an antiherpetically active combination of at least one sulphatised polysaccharide or sulphatized polymer, or at least one salt thereof, for example heparin sodium, and a dissociable zinc salt, for example zinc sulphate heptahydrate, in admixture with a polyethylene glycol mixture of which the constituents have a molecular weight of between 300 and 4000. Such lipsticks may contain further additives, especially polyoxyethylene sorbitan fatty acid esters or sorbitan fatty acid esters. The invention relates also to the use of these lipsticks for the treatment of disorders of the lips and of other areas of the face caused by human herpes viruses.

Antiherpetically active lipstick and the use thereof for the treatment

The invention relates to new pharmaceutical preparations for the topical treatment of infections caused by herpes viruses, especially those which have been caused by herpes virus hominis, for example of herpes genitalis and herpes dermatitis. The preparations contain as antiviral agent a synergistic combination of an acid sulphated polysaccharide or acid sulphated polymer, in particular heparin, and zinc ions, and may further contain polyoxyethylene sorbitan monolaurate and/or -monooleate. They are usual types of preparations for topical administration such as tinctures, solutions, creams, ointments and, especially, gels.

New pharmaceutical preparations

Method for the treatment of herpes infections by administering a compound of the formula ##STR1## in which alk represents alkylene containing 1 to 4 carbon atoms,

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Basel, Switzerland

Bohumir Lukas