Spofa United Pharmaceutical Works

Spofa Spojene Podniky Pro Zdravotnickou

Vyzkumny Ustav Pro Farmacii a Biochemii, Statni Podnik

Spojene Podniky Prozdravotnickou Vyrobu (spofa)

Bohumila Brunova

Jaroslava Grimova

Miroslav Kuchar

Eva Maturova

Oldrich Nemecek

Ludmila Fisnerova

Jiri Kejha

Eva Knezova

Darina Slukova

This invention relates to 5-[4-[-(4,6-dimethyl-2-pyrimidinylsulfamoyl)phenylazo]acetylsalicylic acid (DISALAZINE) is provided as a new compound having anti-arthritic and immunomodulating properties. It can be produced via reaction of the diazonium salt of sulfadimidine reacted with salicylic acid and then acetylating the product anti-arthritic and immunomodulating properties.

5-[4-(4,6-dimethyl-2-pyrimidinylsulfamoyl)phenylazo]acetylsalicylic acid

An etheric derivative of 4(3H)-quinazolinone which is a fluorinated 3-[2-(4-biphenylyloxy)ethyl]-4(3H)-quinazolinone, produced by reacting said 4(3H)-quinazolinone with the corresponding fluorinated 4-(2-chloroethoxy)biphenyl, and its acid addition salts, especially the hydrochloride. This compound possesses substantially higher analgesic activity and lower acute toxicity than aminophenazone, ibuprofen, acetylosalicyclic acid and paracetamol.

Etheric derivative of 4(3H)-quinazolinone and a process for preparation

The invention relates to omega-(2',4'-dihalobiphenylyl)oxo alkanoic acids of Formula: ##STR1## wherein X.sup.1 and X.sup.2 each represent a fluorine or chlorine atom and Y represents a bivalent hydrocarbon chain selected from the group consisting of --CH.sub.2 --CH--CH.sub.3 and (CH.sub.2).sub.3, and to a process for their preparation. The compounds of the invention are highly active and longlasting anti-inflammatory agents.

Omega-(2,4-dihalobiphenylyl) oxo alkanoic acids

Antiinflammatory substituted phenylacetic acids of low toxicity are prepared by reaction of a salt of an alkyl 3 chloro-4-hydroxyphenylacetate with a substituted benzyl halide in the presence of an inert organic solvent at elevated temperatures.

Antiinflammatory substituted phenylacetic acids

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Prague, Czechia

Bohumila Brunova