Spofa, Spojene Podniky Pro Zdravotnickou Vyrobu

Spofa, Pharmaceutical Works

Spofa, Spojene Podniky Prop Farmaceutickou Vyrobu

Bohumil Sevcik

Antonin Cerny

Josef Kral

Jiri Krepelka

Miroslav Semonsky

Karel Rezabek

Miroslav Seda

Marie Auskova

Milan Pesak

Josef Picha

Antonin Borovicka

Marie Krajcrova

Jana Strakova

Maria Fruhaufova

Josef Stuchlik

Petr Bilek

Dagmar Picmausova

Jaromir Hebky

Vladimir Lupinek

Milan Sova

Karel Rezabeck

Jiri Broz

This invention relates to a method for the treatment of endometritis (chronic and/or acute puerperal inflammations) in mammalian females comprising the administration of 1-(8-alpha-ergolinyl)-3,3-diethylurea derivatives of Formula I ##STR1## in which R.sup.1 represents an alkyl group containing 1 to 3 carbon atoms, R.sup.2 represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, and X represents a hydrogen atom or a double bond between the carbon atoms at positions 9 and 10. The compound according to Formula I, or a pharmaceutically acceptable acid addition salt thereof, is the physiologically active component of the therapeutic composition and method. The compound may be combined with a pharmaceutically acceptable diluent, vehicle, excipient, auxiliary, or carrier. The invention is particularly advantageous in veterinary medicine, when applied to the treatment of farm animals, such a cows.

Method for treatment of endometritis in mammalian females

2-Formylquinoxaline-1,4-dioxide cyanoacetylhydrazones evidence significant anticoccidial properties, enhance the feed conversion and stimulate the growth of farm animals. The described compositions are non-toxic and are suitable as veterinary medicaments and feed additives for such animals.

2-Formylquinoxaline-1,4-dioxide cyanoacetylhydrazone and methods for

Novel N.beta.-substituted 8-.beta.-aminoethylergolin-I derivatives and the acid addition salts thereof are disclosed. The described compositions are prepared by either reductive alkylation or selective reduction of corresponding derivatives containing carbonyl groups.

N.beta.-substituted 8-.beta.-aminoethylergolin-I derivatives and their

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Jilove u Prahy, Czechoslovakia

Bohumil Sevcik