Silver Bullet Therapeutics, Inc.

Plethy, Inc.

Silver Bullett Therapeutics, Inc.

Bohdan Wolodymyr Chopko

Paul E Chirico

Houdin Dehnad

Robert Vincent McCormick

Julie Lucero

Jason A Jegge

John Barr

Raja Sundaram

Samuel Linton

John Kraczkowsky

Robert Vincent Mc Cormick

Robert Vincent Mc Cormack

Robert Vincent Mccormick

Antimicrobial metal ion coatings and implants including them. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, rhodium, manganese, niobium or rhenium) on a substrate so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal. The implant may be configured as an implant such as a bone-screw or intramedullary rod-like body configured to receive a treatment cartridge having a coating as described.

Bone implant and systems and coatings for the controllable release of antimicrobial metal ions

Described herein are devices, systems and methods for treating disease and/or infection by the release of silver from an implant over an extended period of time. In particular, the devices described herein may be used to treat infections such as osteomyelitis by the controlled release of silver ions from multiple sites of an extended-use implant. This implant typically includes a plurality of arms that both anchor and help distribute the released ions within the tissue. Power may be applied to release the silver ions into the tissue.

Bone implants for the treatment of infection

Devices, systems, and methods for monitoring health parameters of an individual, including circumferential changes to a portion of the individual's body, are provided herein. A monitoring device includes: a stretchable component configured to fit securely around a body portion, and a sensor module coupled thereto. The sensor module is configured to obtain and transmit a circumference measurement of the body portion. The sensor module may be further configured to obtain and transmit measurements of one or more additional parameters. A related monitoring system includes the described monitoring device and a mobile computing device. The mobile computing device is configured, at least in part, to: process the body circumference measurements to identify and analyze any change in circumference of the body portion, and generate a relevant alert output. Methods performed by the various devices and systems are also provided.

Devices, systems and methods for health monitoring using circumferential changes of a body portion

Silver and/or zinc ion releasing implants, systems and method of operating, inserting and activating/inactivating them are described. In some variations the implant is configured as a bone implant that includes a bone-screw or intramedullary rod like body configured to receive a treatment cartridge having a plurality of ion-releasing members configured as an anode that can controllably engage with a catheter to turn galvanic release of ions on/off as desired. These devices may be configured to release silver ions (and/or zinc ions) above a predetermined level for a predetermined period of time and may maintain a concentration of ions over a relatively large volume of tissue. The ion-releasing members may be configured to reduce or prevent implant movement.

Bone implant and systems that controllably releases silver

Antimicrobial metal ion coatings. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, niobium or rhenium) on a substrate so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal.

Coatings for the controllable release of antimicrobial metal ions

Devices, systems, and methods for monitoring health parameters of an individual, including circumferential changes to a portion of the individual's body, are provided herein. A monitoring device includes: a stretchable component configured to fit securely around a body portion, and a sensor module coupled thereto. The sensor module is configured to obtain and transmit a circumference measurement of the body portion. The sensor module may be further configured to obtain and transmit measurements of one or more additional parameters. A related monitoring system includes the described monitoring device and a mobile computing device. The mobile computing device is configured, at least in part, to: process the circumference measurements to identify and analyze any change in circumference of the body portion, and generate a relevant alert output. Methods performed by the various devices and systems are also provided.

Devices, systems, and methods for health monitoring using circumferential changes of a body portion

Bioabsorbable substrates having antimicrobial metal ion coatings that are well suited for implantation in to a subject's body to treat and/or prevent infection. In particular, described herein are flexible bioabsorbable filaments that are coated with an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, niobium or rhenium) on the filament so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is inserted into a subject's body. The anodic metal may be at least about 30 percent by volume of the coating.

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Henderson, NV, United States of America

Bohdan Wolodymyr Chopko