Institut National De La Recherche Agronomique

Centre National De La Recherche Scientifique

Institut Pasteur

Université Paris—sud

Université Paris-Saclay

Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement

Bogdan Tarus

Anny Slama Schwok

Patrick Couvreur

Didier Desmaele

Felix Augusto Rey

Stéphane Duquerroy

Jean-François Eleouet

Christina Sizun

Bernard Delmas

Stephane Quideau

Helene Bertrand

The present invention relates to N1-benzyl substituted pyrazoles as antiviral agents directed against respiratory syncytial virus.

Antiviral agents directed against respiratory syncytial virus

A pharmaceutical composition for treating viral infections by an influenza type A virus, includes a compound capable of acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of influenza type A viruses, and capable of binding to the viral-RNA-binding domain on the nucleoprotein. A pharmaceutical composition for treating viral infections by an orthomyxovirus, includes a compound capable of acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of orthomyxoviruses, and capable of binding to the viral-RNA-binding domain on the nucleoprotein of the viruses. A compound acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of influenza type A viruses, and binding to the viral-RNA-binding domain on the nucleoprotein of influenza type A viruses and a method for identifying such a compound having these properties are also described.

Antiviral compositions directed against the influenza virus nucleoprotein

Growing community of inventors

Moulins les Metz, France

Bogdan Tarus