Centre National De La Recherche Scientifique

Universitë De Bordeaux

Institut Polytechnique De Bordeaux

Université Joseph Fourier - Grenoble 1

Universite Bordeaux Seagalen

Universite Bordeaux Segalen

Université De Bordeaux 1

Bogdan Catargi

Rachel Auzely-Velty

Jochen Lang

Matthieu Raoux

Gilles Charpentier

Léa Messager

Emilie Hachet

Sylvie Renaud

Valérie Ravaine

Yannick Bornat

Lea Messager

Valerie Ravaine

The invention relates to a sensor () including: a microelectrode assembly (); and &#x3b2;-pancreatic cells () or islets () of Langerhans in culture on the microelectrode assembly (); characterized in that the microelectrode assembly () is designed to measure dynamically, continuously and in real time, electrical signals (V) produced by the &#x3b2;-pancreatic cells () or the islets of Langerhans () upon physiological activation. The invention also relates to the field of devices that can be implantable in the body of a patient, and including an insulin dispenser for dispensing an amount of insulin. The invention also relates to a method for manufacturing such a sensor and to such a device and a use of such a sensor.

Sensor for measuring the activity of beta-pancreatic cells or of islets of langerhans, manufacture and use of such a sensor

Polymer composition comprising a mixture of PBA modified HA polymer grafted on at least a hydroxyl with a group comprising phenylboronic acid and Cis-diol modified HA polymer grafted on at least a hydroxyl with a group comprising a cis-diol. Injectable or implantable glucose-sensitive hydrogels comprising a this polymer composition.

Glucose responsive hydrogel comprising PBA-grafted hyaluronic acid (HA)

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Bordeaux, France

Bogdan Catargi