Siemens Healthcare Diagnostics Products Gmbh

Bodo Fischer

Harald Althaus

Herbert Schwarz

Thomas Wissel

Stefan Teigelkamp

Matthias Ehm

Roland Barten

The present invention is in the area of coagulation analysis and relates to antibodies which bind specifically to an immune complex of prothrombin fragment F2/F1+2 and an F2/F1+2 neoepitope-specific antibody fragment, and to the preparation and the use thereof in methods for determining F2/F1+2.

Antibodies for determining the prothrombin fragment F2/F1+2 in a homogeneous immunoassay

The invention relates to peptides with the Marburg I polymorphism of FSAP and to their preparation and uses, in particular in therapy and diagnosis. The peptides are suitable for use as immunizing antigens for preparing FSAP MR I specific antibodies.

Peptides with the marburg I polymorphism of factor VII-activating protease (FSAP) and their preparation and uses

The invention relates to antibodies which are directed against the FSAP Marburg I variant and to their preparation and use, in particular in therapy and diagnosis. The antibodies are characterized by the fact that they bind specifically to the FSAP MR I variant but not to the FSAP wild-type protein or other mutant variants which are characterized by amino acid substitutions at other positions in the FSAP protein.

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Marburg, Germany

Bodo Fischer