Lts Lohmann Therapie-systeme Ag

Beiersdorf Ag

Other

Lts Lohmann Therapie-systeme Gmbh

Israel Institute for Biological Research

Lts Lohman Therapie-systeme Gmbh & Co. Kg

Lts Lohmann Therape-system Ag

Janssen Pharmaceutica Nv

Bodo Asmussen

Hans-Rainer Hoffmann

Thomas Hille

Michael Horstmann

Walter Muller

Gunter Guse

Klaus Opitz

Markus Krumme

Rudolf Matusch

Steven Minh Dinh

Klaus Schumann

Karin Ludwig

Karsten Cremer

Henning Sattler

Kai K&ouml;pke

Michael Simon

Gunter Borchert

Paul M Gargiulo

Wolfgang Schaefer

Christoph Schmitz

Michael Roreger

Andreas Koch

Mohammad Sameti

Peter Steinborn

Uwe Wortmann

Walter M&uuml;ller

Markus Müller

Rolf Pracht

Hanshermann Franke

Joachim Moormann

Werner Weitschies

Henricus L G M Tiemessen

Georg A Ulex

Yves-Thorsten Przybylla

Holger Piotrowski

Walter Riess

Yacov Meshulam

Aharon Levy

Rainer Dies

Erich Nick

Despina Solomonidou

Johannes Boss

Joerg Kreuter

Christiane Schiller

Stefan Nagel

Gregor Garbacz

Mahmoud A Omer-Adam

The invention relates to a transdermal therapeutic system for the controlled release of water-soluble pharmaceutical active ingredients from an aqueous phase, comprising an occlusive back layer, a central device facing the skin for releasing the agent, an adhesive layer concentrically surrounding the dispensing device and a removable protective film. Said device is made from a stationary solid phase and a liquid phase containing the active ingredient in aqueous solution, the solid phase being formed from a solid with a fleecy or spongy structure.

Transdermal therapeutic system for administering water-soluble peptides and polypeptides

The invention relates to a packaging unit comprising a container and hygroscopic or humidity softenable film-like materials. For this purpose, said film-like materials are stacked in the container and a separating material which is chemically inert and physically stable with respect thereto is arranged at time between said film-like materials. Each time, said separating material is brought into contact with two film-like materials and does not adheres or adheres less strongly to at least one film-like material that to the other film-like material. Said invention makes it possible to develop a packaging unit provided with a container which guarantees a reliable individual withdrawal of the hygroscopic film-like materials.

Wafer vial with inert intermediate layers

Strip-shaped forms of administration for administering an active ingredient via the mucous membrane of the gums.

Gingival wafer

The invention relates to a needle-less, disposable injector comprising a housing (), which has at least one compression bar, a cylinder-piston unit (), a plunger-actuating ram (), a trigger unit () and a spring energy reservoir (), wherein the trigger unit locks the pre-tensioned spring energy reservoir by means of the compression bar. During triggering, the compression bar slides along at least one trigger element () of the trigger unit and, after triggering the trigger unit, the spring energy reservoir displaces the compression bar by means of the plunger-actuating ram and actuates the cylinder-piston unit. When loaded by the pre-tensioned spring energy reservoir, the pairing formed by the mutually facing inner wall of the trigger element and the contact surface of the compression bar has at least in areas a higher sliding friction coefficient than the pairing formed by the mutually facing collar surface of the plunger-actuating ram and the support surface of the compression bar. The present invention provides a disposable injector where the required minimum contact-pressure force is ensured during use thereof.

Disposable injector provided with high injector safety

A single-use injector is disclosed comprising a housing (), arranged in which are at least one mechanical spring energy store (), at least one piston-cylinder unit (), which can be effectively filled at least for a certain time, at least one piston-actuating ram () and at least one triggering unit (). The spring energy store comprises at least one pre-tensioned spring element. The spring-loaded piston-actuating ram () has at least one retaining rod or hook (), which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface of the housing. When actuation occurs, the triggering unit () releases the supporting portion to allow it to move away from the resting surface.

Single-use injector with at least one draw hook

A package for flat, pliable objects, such as for wafer-shaped or film-shaped drug forms. The package has a carrier layer, a cover layer which is detachably connected to the carrier layer, and a first surface region wherein the carrier layer is not connected to the cover layer and is completely surrounded by a margin area. A cavity, enclosed on all sides, is formed for accommodating an object. The package has a second surface region wherein the carrier layer is not connected to the cover layer. At least one perforation line extends at least partially within the second surface region, and is provided both in the carrier layer and in the cover layer. Severing the perforation line forms a free edge of the cover layer which serves as a gripping aid and enables manual removal of the cover layer from the carrier layer. The disclosure further covers a process for packaging flat, pliable objects by forming the above-described package.

Peelable, child-resistant package for film-shaped drug forms

The invention relates to a gastric juice-resistant device for releasing active substance excipients having delayed intestinal passage from a gastric juice-resistant enclosure, and which serves to increase the active substance concentration in the intestines. The inventive device is characterized in that the active substance excipient containing at least one active substance is provided in the form of a multiparticulate preparation whose individual particles have mucoadhesive properties. The invention also relates to a method for producing said device.

Gastric juice-resistant device for releasing mucoadhesive active substance excipients, and method for producing this gastric juice-resistant device

The invention relates to porous, rapidly disintegrating, active substance-containing pellets based on chitosan or a basic chitosan derivative, manufactured according to a dripping method wherein an aqueous solution or dispersion of chitosan or a basic chitosan derivative, one or more active substances, possibly further active substances and an acid is dripped into a cooling liquid having a temperature of maximally &minus;5&deg; C., thereby causing solidification of the solution or dispersion in the form of droplets, and wherein the solidified droplets or pellets are isolated and dried. The invention further relates to the use of these pellets in the manufacture of medicaments or diagnostic agents.

Rapidly decomposing chitosan-based pellets

A form of administration for medical active agents in the form of a blister is characterized in that it contains a transdermal therapeutic system and at least one single dose form of the active agent next to each other.

Blister containing a transdermal therapeutic system and a single dose form of administration

Desoxypeganine and its pharmaceutically acceptable acid addition salts can be used in the treatment of alcoholism. Said substances are administered preferably in a continuos and controlled manner. The pharmaceutical administration form enables controlled release, e.g. for oral, transdermal or another route of parenteral administration.

Pharmaceutical composition containing desoxypeganine for the treatment of alcoholism

A pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system, for the release of the active substance 17-&bgr;-estradiol, contained therein in dissolved form being between its saturation concentration in equilibrium with a gas phase of less than 10% relative air humidity and its saturation concentration in equilibrium with a gas phase of more than 90% relative air humidity, in all matrix levels and, if present, also in an adhesive layer, characterized in that the estradiol quantity contained in in the preparation amounts to at least three times the saturation solubility measured at 95% relative air humidity, and that the air enclosed in the package is adjusted to a relative air humidity between 5% and below 0.5%.

Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-&bgr;-estradiol to the human organism

Desoxypeganine and its pharmaceutically acceptable acid addition salts can be used in the treatment of drug addiction or drug dependence. Said substances are administered preferably in a continuos and controlled manner. The pharmaceutical administration form enables controlled release, e.g. for oral transdermal or another route of parenteral administration.

Pharmaceutical composition containing desoxypeganine for the treatment of drug dependence

Desoxypeganine and its pharmaceutically acceptable acid addition salts are useful in treating nicotine dependence.

Pharmaceutical composition containing deoxypeganine for the treatment of nicotine dependence

The invention relates to a device and method for the treatment of Alzheimer's dementia with desoxypeganine and/or a pharmaceutically acceptable acid addition salt of desoxypeganine.

Use of desoxypeganine in the treatment of Alzheimer's dementia

A therapeutic preparation for the transdermal application of active substances through the skin comprising additives causing an increase in the percutaneous absorption rate of active substances which can normally only insufficiently be absorbed transdermally is characterized by the fact that the additives are HMG-CoA-reductase-inhibitors.

Therapeutic preparation for the transdermal administration of active substances

Growing community of inventors

Bendorf, Germany

Bodo Asmussen