University of Illinois

Purdue Research Foundation

Foxconn Interconnect Technology Limited

Prenosis, Inc.

Bobby Reddy, Jr

Rashid Bashir

Yi-Shao Liu

Chun-Yi Chang

Oguz Hasan Elibol

Muhammad Ashraful Alam

Been-Yang Liaw

Jonghyun Go

Pradeep R Nair

Eric M Salm

Samuel Wachspress

Carlos Duarte-Guevara

Lauren Penrose

Ashraf Alam

Demir Akin

Donald E Bergstrom

Vikhram Vilasur Swaminathan

A stacked testing assembly () includes a microfluidic cartridge () for analyzing a fluid sample and a testing setup, said microfluidic cartridge includes a number of layers () stacked in a height direction with many different kinds of combinations, said testing setup () is capable of assembling and testing all kinds of said layers combinations with no change to the setup.

Microfluidic cartridge and stacked testing assembly with microfluidic cartridge thereof

Provided are methods and devices for the label free detection of analytes in solution, including analytes suspended in a biological fluid. A field effect transistor (FET) is positioned in close proximity to a paired set of reference electrodes and the reference electrodes electrically biased to provide desalting and a stable gate voltage to the FET. In this manner, charged ions are depleted in the sensing region of the sensor and device sensitivity to analyte detection improved by the removal of charge that otherwise interferes with measurement. Also provided are methods and systems providing increased in reference electrode surface area and/or decrease in droplet volume to further improve label-free detection of analytes.

Label free analyte detection by electronic desalting and field effect transistors

Provided herein are methods and devices for measuring pH and for amplifying a pH signal to obtain ultrasensitive detection of changes in pH. This is achieved by providing a sensor and a transducer, wherein the sensor transconductance is sensitive to changes in pH and the transducer transconductance is not affected by pH change. The transducer instead compensates for changes in the sensor transconductance arising from pH change. The unique configuration of the sensor and transducer with respect to each other provides substantial increases in a pH amplification factor, thereby providing pH sensing devices with a giant Nernst response and, therefore, effectively increased pH sensitivity.

Coupled heterogeneous devices for pH sensing

In one aspect, described herein are field effect chemical sensor devices useful for chemical and/or biochemical sensing. Also provided herein are methods for single molecule detection. In another aspect, described herein are methods useful for amplification of target molecules by PCR.

DNA sequencing and amplification systems using nanoscale field effect sensor arrays

Growing community of inventors

Savoy, IL, United States of America

Bobby Reddy, Jr