Smithkline Beecham Corporation

Glaxosmithkline LLC

Bobby Neal Glover

Eric Allen Schmitt

Michele Catherine Rizzolio

Lian-Feng Huang

Barry Riddle Sickles

Robert William Lancaster

Stacey Todd Long

Ronnie Maxwell Lawrence

Matthew Jude Sharp

Maria Fumiko Tymoschenko

Jason William Beames Cooke

The invention relates to crystalline forms of 5,6-dichloro-2-(isopropylamino)-1-&#x3b2;-L-ribofuranosyl-1H-benzimidazole, pharmaceutical compositions comprising the same, processes for preparing the same, and their use in medical therapy.

Crystalline forms of an antiviral benzimidazole compound

The invention relates to crystalline forms of 5,6-dichloro-2-(isopropylamino)-1-&#x3b2;-L-ribofuranosyl-1Hbenzimidazole, pharmaceutical compositions comprising the same, processes for preparing the same, and their use in medical therapy.

An improved process for preparing arylethanoldiamines is described. Compounds of this type are known to be useful as agonists at atypical beta-adrenoceptors (also known as beta-3-adrenoceptors).

Process of preparing arylethanoldiamines

An improved process for preparing arylethanoldiamines is described. Compounds of this type are known to be useful as agonists at a typical beta-adrenoceptors (also known as beta-3-adrenoceptors).

Process

The invention relates to Form physical forms of 5,6-dichloro-2-(isopropylamino)-1-&#x3b2;-L-ribofuranosyl-1H-benzimidazole, pharmaceutical compositions comprising the same, and their use in medical therapy.

The invention relates to Form physical forms of 5,6-dichloro-2-(isopropylamino)-1-&bgr;-L-ribofuranosyl-1H-benzimidazole, pharmaceutical compositions comprising the same, and their use in medical therapy.

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Durham, NC, United States of America

Bobby Neal Glover