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Central Michigan University

Bobby A Howell

Erik W Walles

Patrick B Smith

Cuiwei Zhang

The present invention provides a sustained release composition having hyperbranched polymers that are polyesters that are biobased and biodegradable, and that have at least one active ingredient, which composition delivers the active ingredient over time. These active ingredients can be a wide variety of compounds so long as they can covalently bind to the polymer or be encapsulated in the polymer in a manner that is released at the point of delivery, usually by acid hydrolysis or enzymatic bond scission.

Sustained release composition using biobased biodegradable hyperbranched polyesters

Novel complexes are prepared from water-soluble compounds having at least one amidocarbonylic unit and a square planar organometallic compound.

Macromolecular complexes of amidocarbonylic water-soluble polymers and

Unique, valuable and multifariously utile macromolecular complexes are comprised of: (i) non-ionic, amidocarbonylic, water-soluble polymers (and, for some embodimental purposes, the monomeric precursor(s) thereof), including such known materials as (poly)N-vinylpyrrolidone (i.e., 'PVP') and/or (poly)N-vinyl-5-methyl-2-oxazolidinone (i.e., 'PVO-M') and the hereinafter disclosed like(s) and/or equivalent(s) thereof which, for convenience, may be herein generically identified as 'WSP'; and (ii) square planar configured platinous and, for instant applicancy, equivalently metalled organometallic compounds characterized in containing in ligandal inclusion an aromatic moiety from which depends and to which is connected at least a single distinctly polar substituent group (or 'handle', as it were), such as an hydroxide (i.e., '--OH'), carboxylic acid (i.e., '--COOH') or sulfonic acid - (i.e., '--SO.sub.3 H') unit and/or equivalents thereof as herein disclosed which, for convenience, may for generic identification be herein called an 'SPOM'. The WSP:SPOM complex(es) are associated by non-ionic or other bonding attachment in the nature of hydrogen bonding and/or closely related electrostatic interaction between or through and to the polar substituent in the SPOM and the amidocarbonylic unit in the WSP.

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Mount Pleasant (County of Isabella), MI, United States of America

Bobby A Howell