Glenmark Pharmaceuticals Limited

Glenmark Generics Limited

Bobba Venkata Siva Kumar

Shekhar Bhaskar Bhirud

Nitin Sharad Chandra Pradhan

Batchu Chandrasekhar

Changdev Namdev Raut

Vishvas Dattatraya Patil

Sanjay Anantha Kale

Pravin Bhalchandra Kulkarni

Kosampally Srinivas

Girish Bansilal Patel

A process for the preparation of strontium ranelate or a hydrate thereof is provided comprising (a) reacting a tetraester compound of Formula II: wherein R, R, R, and Rare independently a linear or branched C-Calkyl group or a substituted or unsubstituted C-Ccyclic group, in the presence of a lithium base and in a solvent with an inorganic acid salt of strontium. 

Process for the preparation of strontium ranelate

A process for preparing a crystalline form of linezolid is provided comprising (a) providing a solution comprising linezolid in an organic solvent having a boiling point of less than or equal to about 150&#xb0; C.; (b) adding an anti-solvent having a boiling point greater than or equal to about 50&#xb0; C. to the solution; and (c) recovering the crystalline form of linezolid.

Process for the preparation of a crystalline form of (S)-N [[3-(3-fluoro-4(4-morpholinyl) phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide

An improved process for the preparation of key intermediates for tazarotene, 4,4-dimethyl-6-ethynylthiochroman, is provided comprising (a) reacting 4,4-dimethyl-6-acetylthiochroman of the formula with an acid chloride and an amido-group containing compound of the general formula wherein R is hydrogen or a hydrocarbyl of from 1 to 15 carbon atoms and Rand Rcan be the same or different and are hydrocarbyls of from 1 to 15 carbon atoms or Rand Rtogether with the nitrogen atom to which they are bonded are joined together to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms, or one of Rand Rtogether with the nitrogen atom to which it bonded are joined together with the carbonyl radical to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms to form a &#x3b2;-chloro vinyl carbonyl compound intermediate of the general formula wherein R has the aforestated meanings; and (b) reacting the &#x3b2;-chloro vinyl carbonyl compound intermediate with an alkali metal to provide the 4,4-dimethyl-6-ethynylthiochroman.

Process for the preparation of 4,4-dimethyl-6-ethynylthiochroman

An improved process for the preparation of key intermediates for tazarotene, 4,4-dimethyl-6-ethynylthiochroman, is provided comprising (a) reacting 4,4-dimethyl-6-acetylthiochroman of the formulawith an acid chloride and an amido-group containing compound of the general formulawherein R is hydrogen or a hydrocarbyl of from 1 to 15 carbon atoms and Rand Rcan be the same or different and are hydrocarbyls of from 1 to 15 carbon atoms or Rand Rtogether with the nitrogen atom to which they are bonded are joined together to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms, or one of Rand Rtogether with the nitrogen atom to which it bonded are joined together with the carbonyl radical to form a heterocyclic group, optionally containing one or more additional heterocyclic atoms to form a &#x3b2;-chloro vinyl carbonyl compound intermediate of the general formulawherein R has the aforestated meanings; and (b) reacting the &#x3b2;-chloro vinyl carbonyl compound intermediate with an alkali metal to provide the 4,4-dimethyl-6-ethynylthiochroman.

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Navi Mumbai, India

Bobba Venkata Siva Kumar