Schering Aktiengesellschaft

Bob Nieuweboer

Helmut Vorbrueggen

Werner Skuballa

Ulrich Klar

Bernd Raduechel

Gerda Mannesmann

Helmut Vorbruggen

Claus-Steffen Stuerzebecher

Claus-Steffen Sturzebecher

Ulrich Kerb

Karl Petzoldt

Jorge Casals-Stenzel

Ekkehard Schillinger

Werner Krause

Michael H Town

Paul-Eberhard Schulze

Michael-Harold Town

Otto Engelfried

Michael Humpel

Klaus Lubke

The invention relates to carbacyclin derivatives of Formula I ##STR1## wherein the various substituents are defined herein, including, inter alia,

9-substituted carbacyclin derivatives, processes for their preparation,

The invention relates to carbacyclin derivatives with general formula I: ##STR1## in which Y.sub.1 stands for the radical --CH.sub.2 --X--(CH.sub.2).sub.n --R.sub.1 or the radical ##STR2## n, 1 or 3, R.sub.1, the radical ##STR3## the radical ##STR4## R.sub.9 stands for the radical --(CH.sub.2).sub.m --R.sub.6 or the radical --(CH.sub.2).sub.m-o --[Z.sub.1 --(CH.sub.2).sub.m-p ].sub.x --[Z.sub.2 --(CH.sub.2).sub.m-q ].sub.y --R.sub.6,

Carbacyclins, processes for their preparation, and their use as

The invention relates to a process for the determination of small substance quantities of medicines, of endogenous or other chemical compounds in biological material, characterized by either binding the compound to be determined and its deuterated analog to an antibody present in excess, which antibody is coupled to a stationary phase of a polymeric material, and separating the two compounds from the antibody and measuring by mass spectrometry the proportion of deuterated compound/not deuterated compound or, respectively, cross-reacting compound; or, in case a suitable deuterated or cross-reacting compound is not available, utilizing as the internal standard also a chemically similar compound which, however, is added after the antibody-mediated extraction, and inserting a separating process before mass spectrometry.

Method for the determination of small substance quantities of medicines,

Novel 9-substituted carbacyclin derivatives, processes for their

The invention also relates to carbacyclin derivatives of general formula I' ##STR1## wherein R.sub.9 is an alkyl group of 1-10 carbon atoms or the group --C.dbd.C--(CH.sub.2).sub.m --R.sub.6 wherein

New carbacycline, process for their production and their use as a drug

Carbacyclin esters of Formula I ##STR1## wherein R.sub.1 is an unsubstituted or substituted aromatic residue,

Novel carbacyclin esters, process for the preparation thereof, and their

Carbacyclinamides of Formula I ##STR1## wherein R.sub.1 is NHR.sub.4, wherein R.sub.4 is H, --(CH.sub.2).sub.n --R.sub.8 or straight-chained or branched aliphatic groups of 1-10 carbon atoms, cycloalkyl of 3-10 carbon atoms, aryl, or lower mono- or polyhydroxyalkyl of 2-8 carbon atoms, or R.sub.1 is NR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 each are straight-chained or branched, lower, mono- or polyhydroxyalkyl of 2-8 carbon atoms, or R.sub.4 and R.sub.5 together with the adjoining N-atom form a 5- or 6-membered heterocycle which can optionally contain additional hetero atoms and can be substituted; or R.sub.1 is NR.sub.4 R.sub.5 wherein R.sub.4 is an aliphatic group of 1-10 carbon atoms, cycloalkyl of 3-10 carbon atoms, and R.sub.5 is straight-chained or branched aliphatic group of 1-10 carbon atoms, cycloalkyl of 3-10 carbon atoms, aryl, or lower, mono- or polyhydroxyalkyl of 2-8 carbon atoms;

Novel carbacyclinamides, their preparation and use as medicinal agents

Compounds of Formula I ##STR1## wherein X is oxygen or CH.sub.2 ;

Carbacyclins, their preparation and pharmacological use

Steroids bearing the substituent --X-NR.sub.1 R.sub.2 wherein --NR.sub.1 R.sub.2 is a tritium of carbon-14 labeled amino or amino-acid group and --X-- is --R.sub.3 --, --OCOR.sub.3 --, =N--O--R.sub.3 -- or --NHCOR.sub.3 -- wherein R.sub.3 is --(CH.sub.2).sub.n CO-- in which n is 0-4, are useful as diagnostic agents.

Growing community of inventors

Berlin, Germany

Bob Nieuweboer