The General Hospital Corporation

Harvard College

Children's Medical Center Corporation

University of California

Bob Carter

Richard C Mulligan

Jeng-Shin Lee

Szofia S Bullain

Xandra O Breakefield

Johan Karl Olov Skog

Mikkel Noerholm

Anders M Dale

Clark Chen

Tyler Steed

Provided are chimeric VEGF-binding proteins and nucleic acids (e.g., a vector) encoding chimeric VEGF-binding proteins, methods and host cells for producing these proteins and nucleic acids, and pharmaceutical compositions containing these proteins and nucleic acids. Also provided are methods of treating an angiogenic disease or disorder that include administering at least one of the chimeric VEGF-binding proteins or at least one of the nucleic acids (e.g., a vector) encoding a chimeric VEGF-binding protein.

VEGF-binding protein for blockade of angiogenesis

The invention concerns gene signatures obtained from microvesicles and a method of applying these gene signatures in helping to determine a biological condition. The determination of a biological condition may aid, for example, the diagnosis, prognosis, and therapy treatment selection for disease in a subject.

Use of microvesicles in analyzing nucleic acid profiles

Techniques, systems, and devices are described for implementing automatic segmentation and quantitative parameterization of MRI images. For example, the disclosed method includes processing the MRI image to correct any distortions; performing a preliminary segmentation of the MRI image to assign a tissue label of a set of tissue labels to one or more preliminary volumes of voxels of the MRI image; comparing each voxel of the MRI image with the one or more preliminary volumes of voxels with an assigned tissue label and assigning each voxel of the MRI image a probability of being associated with each tissue label of the set of tissue labels; and assigning each voxel of the MRI image a tissue label according to its greatest probability among probabilities for each voxel being associated with the set of tissue labels.

Automatic segmentation and quantitative parameterization of brain tumors in MRI

Growing community of inventors

San Diego, CA, United States of America

Bob Carter