Cardiovalve Ltd.

Ams Research Corporation

Vascular Graft Solutions Ltd.

Mininvasive Ltd.

Mitraltech Ltd.

Niti Surgical Solutions Ltd.

Tel Hashomer Medical Research Infrastructure and Services Ltd.

Niti Medical Technologies Ltd.

Regentis Biomaterials Ltd.

Intellimats, LLC

American Medical Systems, Inc.

Universit&#xe4;t Z&#xfc;rich

Vectorious Medical Technologies Ltd.

Lydus Medical Ltd.

Intellimat, Inc.

Boaz Harari

Ilia Hariton

Meni Iamberger

Aviram Baum

Amir Perle

Michael Arad

Mordechay Beyar

Oren Globerman

Leonid Monassevitch

Kobby Greenberg

Dror Rosner

Eyal Orion

Ronen Raz

Oded Meiri

Doron Kopelman

Ehud Raanani

Boris Orlov

Maxim Karalnik

Lichen Rozitsky

Ronald D Blum

William Kokonaski

Michael Albitov

Youval Katzman

Boaz Shenhav

Paul Mraz

Shlomo Lelcuk

Kimberly A Anderson

Raphael Meloul

Arnon Mousaiuf

Yelena Kasimov

Raz Simon

Shahar Millis

Alex Geller

Amir Szold

Amol Bapaye

Karny Jacoby

Dwight P Duston

Mordehai Sholev

Andrea Guidotti

Yair Feld

Joseph Thibodeau

Oren Goldshtein

Oded Katzman

Raz Bar-On

Bradley J Blum

Paul Kaye

Kamal Daas

Dean Ad-El

Francesco Maisano

Muhamad Mansur

Guy Ohad

J Thomas Walker

Barry H Whalen

Georgios Stefopoulos

Yair Levi

Moti Sholev

Mordechai Sholev

Joseph A Thibodeau

Kobby Greenburg

Yaakov Greenberg

Ronen Neeman

Pietro Gozzoli

Monica Tocchi

Luca Vicentini

Jessica Weiss

Shai Golan

A valve frame includes a tubular portion defining a plurality of valve-frame coupling elements disposed circumferentially around a longitudinal axis of the valve frame, and a plurality of arms, extending radially outward from an upstream portion of the tubular portion to define an arm span, and configured to engage tissue in the atrium. An outer frame is coupled to the valve frame, and includes a ring circumscribing the tubular portion, and a plurality of flanges that extend radially outward from the ring to define a flange span, and are configured to engage ventricular tissue. Each arm defines a rigid portion and a flexible portion that is disposed radially outward from the rigid portion, and is more flexible than the rigid portion. The majority of the flexible portion is disposed further radially outward than the flange span. Other embodiments are also described.

Prosthetic valve with arms and flanges

Provided is an anastomosis arrangement for joining two opposite stumps of a tubular organ in a streamlined anastomosis procedure. The arrangement includes a pair of axially symmetric stump-coupling members that accommodate pairs of counterpart suturing needles, linked together by common suturing threads, and manipulable by a needle-manipulation element to extract the needles tips from the stump-coupling members for piercing walls of the stump.

Anastomosis device

A prosthetic valve is provided that includes a tubular valve body and a plurality of prosthetic leaflets disposed within a lumen of the valve body. The valve body includes struts, has an upstream end and a downstream end, and defines a lumen. The valve body is shaped so as to define a circumferential row of four-sided closed cells. Each of the four-sided closed cells is defined by some of the struts, which are shaped so as to collectively define the following four sides: a left upstream side, a right upstream side, a left downstream side, and a right downstream side. Exactly two of the four sides of each of the four-sided closed cells are double-strutted. Other embodiments are also described.

Prosthetic heart valve

An expandable prosthetic valve is implantable within a native mitral valve by terminal ends of ventricular anchors of the prosthetic valve moving outwardly from a constrained delivery position of the ventricular anchors, while the ventricular anchors are positioned within the atrium. Then, a portion of the expandable prosthetic valve containing the ventricular anchors is advanced through the native mitral valve into the ventricle. Terminal ends of atrial anchors of the prosthetic valve move outwardly relative to a portion of an annular valve body of the prosthetic valve while the atrial anchors are at least partially positioned within the atrium. Next, the annular valve body is radially expanded while the ventricular anchors are in the ventricle and the atrial anchors are in the atrium, thereby anchoring native heart valve tissue between the atrial anchors and ventricular anchors. Other embodiments are also described.

Systems and methods for implanting a prosthetic valve within a native heart valve

Apparatus and methods are described including placing a valve frame within a subject's heart. The valve frame includes a valve frame body that is configured to support the prosthetic valve within the native atrio-ventricular valve, and at least one arm that is configured to extend from a ventricular portion of the valve frame. The at least one arm is deployed among chords of the native atrio-ventricular valve. Subsequently, at least a portion of the valve frame is rotated in a direction in which an interior of the arm faces, such as to modify shapes of the native valve leaflets and the ventricular structures, by recruiting and deflecting at least a portion of the chords. The frame body of the valve frame is then radially expanded, such as to hold the native valve leaflets and the ventricular structures at least partially in the modified shapes. Other applications are also described.

Ventricular structure reshaping atrio-ventricular valve

A prosthetic valve includes a tubular portion coupled to an upstream support portion, and ventricular legs. The prosthetic valve is transitionable from a compressed state into a partially-expanded state in which (1) a downstream surface of the support portion defines (i) an annular concave region extending radially between a concave-region inner radius and a concave-region outer radius, and (ii) an annular convex region, radially outward from the annular concave region, extending radially between a convex-region inner radius and a convex-region outer radius, and (2) the tip of each leg is disposed radially between the concave-region inner radius and the concave-region outer radius. In a fully-expanded state each leg's tip is disposed radially between the convex-region inner radius and the convex-region outer radius. Other embodiments are also described.

A prosthetic valve is provided that includes a tubular valve body and a plurality of prosthetic leaflets disposed within a lumen of the valve body. The valve body includes struts arranged in a cellular structure defined by first and second circumferential rows of four-sided closed cells. Each of the four-sided closed cells is defined by some of the struts, which are shaped so as to collectively define the following four sides: a left upstream side, a right upstream side, a left downstream side, and a right downstream side. The struts are joined at four corners of the four-side closed cell. Each of the four sides of each of the four-sided closed cells is double-strutted. Other embodiments are also described.

A delivery tool includes a nosepiece that is fixed to a shaft, and distal to an implant, and an expandable element proximal to the nosepiece. Maximally-expanded, the expandable element (i) has an expanded external diameter at its widest part that is smaller than the expanded internal diameter of a lumen of the frame of the implant, (ii) tapers proximally away from the widest part and from the nosepiece, and (iii) is dimensioned to slide proximally through the lumen of the implant in its expanded state, between leaflets of the implant, and out of the lumen. When non-expanded, the widest part of the expandable element has a non-expanded external diameter that is smaller than the expanded external diameter of the expandable element. In a compressed state of the implant a portion of the expandable element is disposed within the lumen of the frame. Other applications are also described.

Minimally-invasive delivery systems

A prosthetic valve is provided that includes a tubular valve body and a plurality of prosthetic leaflets disposed within a lumen of the valve body. The valve body includes struts, has an upstream end and a downstream end, and defines a lumen. The valve body is shaped so as to define a circumferential row of four-sided closed cells. Each of the four-sided closed cells is defined by some of the struts, which are shaped so as to collectively define the following four sides: a left upstream side, a right upstream side, a left downstream side, and a right downstream side. Each of the four sides of each of the four-sided closed cells is double-strutted. Other embodiments are also described.

A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body. The prosthetic valve may also include a plurality of tissue anchors arranged about the valve body and configured to extend from connection points on the valve body. The prosthetic valve may also include at least one protective fabric covering extending over each of the connection points between each tissue anchor and the valve body.

Prosthetic valve with protective fabric covering around tissue anchor bases

A method for testing a prosthetic heart valve leaflet is provided. The method includes using a vertical post having a longitudinal axis and a horizontal bar having a bar-axis that lies on a vertical bar-plane. The bar supports the leaflet along the bar-axis such that the leaflet drapes over the bar. A linear actuator movably couples the bar to the post, and actuation of the actuator moves the bar vertically in the bar-plane. A light source emits a beam of light and is oriented to direct the beam through the bar-plane. A gauge measures an elevation of the bar above the beam. A detector is positioned to detect the beam and generates a detection-signal indicative of detection of the beam. Other applications are also described.

Techniques for use with prosthetic valve leaflets

An occlusion device () is provided for occluding a left atrial appendage (LAA), including a compliant balloon () defining a fluid-tight balloon chamber (), and an actuating shaft (), which is disposed at least partially within the balloon chamber () for setting a distance between distal and proximal end portions () of the balloon (). A proximal LAA-orifice cover () includes a frame () and a covering () fixed to the frame (). An orifice-support stent () is fixed to and extends distally from the proximal LAA-orifice cover (), and is generally cylindrical when in a radially-expanded state. Other embodiments are also described.

Left atrial appendage occlusion devices

Embodiments of the present disclosure include a method for use at a native valve of a heart of a subject. At a distal portion of a delivery tool, a balloon is coupled to a shaft. The distal portion is advanced to the heart with an implant and the balloon disposed within a capsule. The implant includes a tubular frame and one or more shape-memory flanges. The tubular frame is compressed around the balloon, and the flanges are constrained within a downstream capsule-portion of the capsule. The flanges are exposed from the downstream capsule-portion such that the flanges automatically deflect radially outward. Subsequently, the flanges are pressed against a downstream surface of the native valve by moving the implant in an upstream direction. While the flanges are in contact with the downstream surface, the tubular frame is plastically expanded radially by inflating the balloon. Other embodiments are also described.

Prosthetic valve and delivery tool therefor

An expandable prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an expandable annular valve body. The valve body may include an atrial inlet opening and a ventricular outlet opening. The valve body may additionally include a plurality of tissue anchors extending from the valve body. The prosthetic valve may additionally include a flexible annular protective sleeve positioned about the rim of the valve body outlet opening and affixed to the outlet opening.

Prosthetic valve with protective sleeve around an outlet rim

A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body and a plurality of atrial anchoring arms and a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. The prosthetic valve may also include a blood-inflatable cuff situated between the arms and legs and fastened to at least one arm. The cuff may be configured to extend radially outward beyond a terminal end of at least one arm when fully inflated with blood.

Prosthetic valve with inflatable cuff configured for radial extension

Growing community of inventors

Ganey Tikva, Israel

Boaz Harari