Prochon Biotech Ltd.

Hepacore Ltd

Bio-technology General (israel) Ltd.

Bio-technology General Corporation

Boaz Amit

Avner Yayon

Avraham Wortzel

Roy Sirkis

Hilla Barkay-Olami

Conjugates of hydrophilic carboxy polysaccharides with protein members of the fibroblast growth factor (FGF) family and variants thereof. The conjugates provide a modified bioactivity and stability of FGFs for various therapeutic applications.

Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof

Disclosed are chemically modified hyaluronic acid (HA) derivatives containing hydrazido groups directly linked to the glucuronic acid residues of HA. Said hydrazido groups are used to obtain crosslinked and labeled HA derivatives. The invention further relates to methods of preparation of said HA derivatives.

Hydrazido derivatives of hyaluronic acid

The present invention provides water-soluble reactive esters of carboxy polysaccharides and derivatives thereof. The reactive carboxy polysaccharide derivatives are useful per se in aqueous solutions or specifically for the formation of water-soluble covalent fibrinogen conjugates. A preferred conjugate is a hyaluronic acid-fibrinogen conjugate and fibrin adhesive, clot or matrix derived from it. Methods of preparation and methods of use in tissue repair and regeneration are also disclosed.

Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof

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Kiryat Ono, Israel

Boaz Amit