Leland Stanford Junior University

Nirmidas Biotech, Inc.

Bo Zhang

Hongjie Dai

Scott M Tabakman

Guosong Hong

Su Zhao

Meijie Tang

Joshua T Robinson

Anna Hsu Pao

Jeyarama Subramanian Ananta Narayanan

Disclosed herein are systems and methods for detecting and diagnosing flaviviral or alphaviral infections in subjects in need thereof. The systems and methods of the disclosure enable rapid testing of small volumes of biological sample with the ability to reliably distinguish between flavival and alphaviral infections and determine whether the viral infection is acute or chronic.

Methods and systems for diagnosis and treatment of viral infections

Disclosed are nanostructured gold films which may be produced by solution-phase depositions of gold ions onto a variety of surfaces. The resulting plasmonic gold films are used for enhanced spectroscopic-based immunoassays in multiplexed microarray format with detection mechanisms based on either surface-enhanced Raman scattering or near-infrared fluorescence enhancement. The preparation of the films and subsequent modifications of the gold film surfaces afford increased sensitivity for various microarrays. The films are discontinuous, forming gold 'islands.' Sensitivity, size, shape, and density of the nanoscopic gold islands comprising the discontinuous nanostructured gold film are controlled to enhance the intensity of Raman scattering and fluorescence in the near-infrared, allowing for improved measurements in clinical diagnostic or biomedical research applications.

Fluorescence enhancing plasmonic nanoscopic gold films and assays based thereon

Growing community of inventors

Stanford, CA, United States of America

Bo Zhang