Medtronic Minimed, Inc.

Københavns Universitet

Kobenhavns Universitet

Precisense A/s

Bo Wegge Laursen

Jens Christian Norrild

Thomas Just Sorensen

Martin Rosenberg

A method for the production of a sol-gel based matrix resulting in a sol-gel based matrix with high stability and high porosity. The sol-gel based material may be used for the production of a composite or sensor suitable for monitoring analytes.

Sol-gel based matrix

The present invention relates to a method for the production of a sol-gel based matrix. The method comprises the steps of: a) providing a first alkoxysilane of the general formula: R&#x2014;Si(OR)and a second alkoxysilane of the general formula (I): b) preparing a first sol-gel component by polymerization of the first alkoxysilane in the presence of an acid catalyst, c) preparing a second sol-gel component by polymerization of the second alkoxysilane in the presence of an Lewis acid catalyst, d) Mixing the first sol-gel component and the second sol-gel component for the preparation of a sol-gel based matrix. The above method results in a sol-gel based matrix with high stability and high porosity. The sol-gel based material may be used for the production of a composite or sensor suitable for monitoring analytes. Methods for preparing these composites or sensors are provided as well.

A reagent for use in detecting an analyte comprises a fluorescent energy donor and an energy acceptor, wherein the energy acceptor is of the general formula: and wherein the distance between the energy donor and the energy acceptor of the reagent is capable of modulation by a suitable analyte to be detected.

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Roskilde, Denmark

Bo Wegge Laursen