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Astra Lakemedel Aktiebolag

Biogram Ab

Bo T Af Ekenstam

Gunnar A Aberg

Kare V Larsson

Peter R Maroko

Per-Olof Glantz

Christer Bovin

The local anesthetic, L-N-n-propylpipecolic acid-2,6-xylidide, namely: ##STR1## This compound is prepared by chlorinating L-pipecolic acid to yield the acid chloride, namely L-pipecolic acid chloride. The acid chloride is then reacted with 2,6-xylidine to yield L-pipecolic acid-2,6-xylidide. The L-N-pipecolic acid-2,6-xylidide is then propylated to yield the L-N-n-propylpipecolic acid-2,6-xylidide, which is a potent local anesthetic for humans and is of relatively low toxicity.

L-N-n-propylpipecolic acid-2,6-xylidide

A germicidal composition consists of an aqueous suspension of hydrophilic lipid crystals of 1-monolaurin, and preferably also 1-monomyristin, in a quantity of 20-30 percent by weight, and hydrogen peroxide in a quantity of 0.2-5 percent by weight. The hydrophilic lipid crystals stabilize the hydrogen peroxide, to the effect that the composition retains its germicidal power even after having been stored for a long time. Also, the peroxide disintegrates slowly when the composition has been applied onto skin or mucous membrane.

Germicidal composition

A method and pharmaceutical composition are disclosed for treating cardiac arrhythmias employing as an active ingredient at least one compound selected from piperidine-2-carboxylic acid-2,6-dimethyl anilide; piperidine-2-carboxylic acid-2,4-dimethyl anilide; piperidine-2-carboxylic acid-2,4,6-trimethyl anilide; and piperidine-2-carboxylic acid-2-methyl-5-chloro anilide.

Method and composition for the treatment of cardiac arrhythmias

A compound of formula ##STR1## in which m and n are a pair of integers such that m=0 or 1 and n=3-m or m=0, 1 or 2 and n=4-m, R is straight or branched C.sub.2 to C.sub.4 alkyl having a terminal hydroxy group,

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Hjalteby, Sweden

Bo T Af Ekenstam