Ab Kabi

Other

Landstingens Inkopscentral

Bo T Af Ekenstam

Karl G Claeson

Leif E Aurell

Birgitta G Karlsson

Stig I Gustavsson

Gun A Olausson

Gunnar A Aberg

Erik G Nordqvist

Compounds of the formula (I) ##STR1## optically active isomers thereof, and/or pharmaceutically acceptable acid addition salts thereof are disclosed, wherein R.sup.1 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, n-butyl, 2-hydroxyethyl, 3-hydroxypropyl and 4-hydroxybutyl, and wherein R is selected from the group consisting of ##STR2## in which R.sup.2, R.sup.3 R.sup.4 and R.sup.5 are the same or different and are each independently selected from the group consisting of hydrogen and methyl. Pharmaceutical preparations employing such compounds and method of using such compounds are also disclosed.

Membrane stabilizing phenoxy-piperidine compounds and pharmaceutical

A method of dispensing fluid or semi-fluid liquids or pastes in which the liquid or paste is contained in a container having a top flexible dome and a bottom dome connected at their open ends to each other. The method comprises pressing the top dome downwardly toward the bottom dome and forcing the top dome into the bottom dome and discharging the liquid or paste from the bottom dome under the action of the forcing of the top dome into the bottom dome. The top dome can be formed with an internal annular bead which is displaced along the inner walls of the bottom dome to scrape off material stuck to the inside walls of the bottom dome.

Method for discharge of quantities of fluid or semi-fluid substances

A chromogenic substrate having the formula ##STR1## and salts thereof wherein R.sub.1 is H or OH, R.sub.2 is a chromophoric group, and n is 1, 2 or 3.

Novel chromogenic thrombin substrates

Method for the quantitative determination of serine proteases which includes contacting the substance for which the determination is desired with a diagnostically active chromogenic substrate with good stability and high specificity to serine proteases having the formula: H--D--A.sub.1 --A.sub.2 --A.sub.3 --NH--R or salts thereof, wherein A.sub.1 is Gly, Ala, Val, Leu, Ile, Pip, Pro, or Aze; A.sub.2 is Gly, Ala, Val, Leu, Ile, Pip, Pro, Aze, or Phe; A.sub.3 is Arg, Lys, or Orn, and R is a chromophoric group.

Assay of serine proteases using novel chromogenic enzyme substrates

Process for determining thrombin and thrombin-like enzymes employing a substrate having the formula: ##STR1## and salts thereof, wherein R.sub.1 is H or OH; R.sub.2 is a chromophoric group; the N-terminal amino acid is in the D configuration and n is 1, 2 or 3 provided along with the method of use.

Diagnostically active chromogenic substrate with good stability and high specificity to serine proteases having the formula: H-D-A.sub.1 -A.sub.2 -A.sub.3 -NH-R or salts thereof, wherein A.sub.1 is Gly, Ala, Val, Leu, Ile, Pip, Pro, or Aze; A.sub.2 is Gly, Ala, Val, Leu, Ile, Pip, Pro, Aze, or Phe; A.sub.3 is Arg, Lys, or Orn, and R is a chromophoric group.

Growing community of inventors

Molndal, Sweden

Bo T Af Ekenstam