Samsung Electro-mechanics Co., Ltd.

Samsung Life Public Welfare Foundation

Mbd Co., Ltd.

Sungkyunkwan University

Mbd Korea. Co., Ltd.

Bo Sung Ku

Sang Jin Kim

Dong Woo Lee

Tae Yoon Kim

Young-Ho Cho

Jeong Suong Yang

Young Soo Oh

Sung Koo Kang

Sang Youl Jeon

Do Hyun Nam

Hee Ju Son

Jung Eun Kim

Sang Hyun Yi

Don Jung Lee

Yeon Sook Choi

Man Ki Chung

Myung Yong Eom

The present invention is directed to a method of measuring cell migration by measuring the invasion ratio of cells incubated on a pillar array inserted into a well structure, the method including steps of: preparing a pillar array having a plurality of micropillars and a well structure having a plurality of microwells into which the plurality of micropillars is insertable, respectively; forming cell spheroids by incubating cells in an extracellular matrix attached to the end contact surfaces of the micropillars; allowing the cells contained in the cell spheroids to invade the end contact surfaces; staining and scanning the cell spheroids, the cells contained in the cell spheroids, and the cells that invaded the end contact surfaces; and calculating the invasion ratio of cells by the following equation through a fluorescence image of the scanned cells: wherein Arepresents the total cell area, and Arepresents the spheroid area.

Measuring method of cell migration using the rate of cell invasion

The present invention relates to a pillar structure for a biochip, the pillar structure including: a substrate portion which has a plate-shaped structure; multiple pillar portions which protrude from one surface of the substrate portion and each of which has an end portion on which a sample is disposed; and smooth surface forming portions which are formed on the other surface of the substrate portion that defines the plate-shaped structure together with the one surface of the substrate portion, the smooth surface forming portions forming smooth surfaces each having a relatively concave groove shape at a portion corresponding to a circumferential surface of each of the pillar portions.

Pillar structure for biochip

The present invention relates to a pillar structure for a biochip and includes a substrate which has a plate-shaped structure, and pillar members, each of which has one side detachably coupled to the substrate and the other side on which a sample is disposed.

A cell analysis apparatus may include: an image processing unit imaging cultured cell colonies to convert the imaged cell colonies into digital signals; an outline extracting unit extracting outlines of the cell colonies from image data obtained from the image processing unit; a size calculating unit calculating sizes of the cell colonies from the extracted outlines; and a selecting unit comparing the sizes of the cell colonies with a preset value to select grown cell colonies.

Cell analysis apparatus and method

There is provided a valve membrane including: a thin film member; a first opening and closing member formed by a first cutting line to cut one part of the thin film member and opened by a fluid moving in a first direction; and a second opening and closing member formed by a second cutting line to cut the other part of the thin film member and opened by a fluid moving in a second direction.

Valve membrane and check valve

There is provided a micro-pump including: a bottom substrate; a flow path forming substrate coupled to the bottom substrate and including an inlet having a fluid introduced therein and an outlet having the fluid ejected therefrom; and a valve substrate coupled to the flow path forming substrate and including at least one valve controlling the fluid to be introduced and ejected.

Micro-pump

Disclosed herein is a chip for inspecting toxicity and efficacy, including: a first substrate including fitting holes formed at corners thereof; and a second substrate including gap forming members formed at corners thereof corresponding to the fitting holes to form a gap between the first substrate and the second substrate, and protrusions formed on the gap forming members corresponding to the fitting holes and fitted in the fitting holes. The chip for inspecting toxicity and efficacy is advantageous in that alignment of the chip can be easily performed, in that problems with the emission of fluorescence or the penetration of measuring light in the chip can be solved, and in that the cost of producing the chip can be reduced.

Chip for inspecting toxicity and efficacy

There is provided a micro pump, including: a channel forming substrate having an inlet and an outlet; an upper substrate connected to the channel forming substrate and having a first hole connected to the inlet and a second hole connected to the outlet; and an adhesive member disposed between the channel forming substrate and the upper substrate to bond the channel forming substrate and the upper substrate and having a first valve opening and closing the inlet and a second valve opening and closing the outlet.

Micro pump

Disclosed herein is a stamping apparatus for biochips and a method of operating the stamping apparatus. The apparatus includes a table, a first chip table, a second chip table, a stamping unit and a control unit. The first chip table is provided on the table. A first biochip is seated onto the first ship table. A second biochip is seated onto the second chip table. The stamping unit is mounted to the table and operates the second chip table such that a surface of a junction of the second biochip seated on the second chip table is joined to a surface of a junction of the first biochip seated on the first chip table. The control unit controls operation of the first chip table or the second chip table.

Stamping apparatus for biochips and method for operation thereof

There is provided a bio-chip, including a fixing plate having a plurality of guide grooves formed in one surface thereof, a first substrate having a plurality of support plates inserted into the guide grooves, and a plurality of pillars protruded from one surface of the respective support plates, and having a biomaterial disposed thereon.

Bio-chip

There is provided a biochip stamping device. The biochip stamping device includes a stamping jig in which a first biochip is aligned; an inverting mechanism vertically inverting a second biochip; and a movement mechanism transferring the vertically inverted second biochip on the stamping jig to combine the first biochip and the second biochip.

Biochip stamping device and stamping method thereof

Disclosed herein are a cell chip and a method for manufacturing the same. The cell chip may include: a substrate; and a first contact member disposed on the substrate, wherein a top end of the first contact member is provided with a first inclined contact surface inclined with respect to the substrate.

Cell chip and method for manufacturing the same

There is provided a micro-ejection device including: an ejector ejecting a fluid; and a body having an installation space in which the ejector is installed, wherein the installation space is provided with a guide unit inducing a line-contact or a point-contact between the ejector and the body.

Micro-ejection device

According to a device and system for measuring the properties of cells, there is an advantage in that, since a cell accommodation unit having a volume is provided, the properties of three-dimensional cells can be measured. Further, the present invention is advantageous in that it enables passive measurement of multiple properties which passively measures the electrical, mechanical and/or optical properties of cells, and active measurement of multiple properties which actively applies electrical, mechanical and optical types of stimulation to cells and measures their electrical, mechanical and/or optical reactions, thus measuring the multiple properties of cells with high reliability.

Device and system for measuring properties of cells and method of measuring properties of cells using the same

Disclosed herein is a droplet receiver. The droplet receiver includes an internal space formed such that its sectional area is reduced towards an input part, thus preventing the rebounding of droplets which enter a droplet receiving part, and includes an intercepting fluid layer so as to isolate the received droplets from the outside, thus preventing droplets received in the droplet receiving part from being contaminated and volatilizing.

Growing community of inventors

Gyunggi-do, South Korea

Bo Sung Ku