Mayo Foundation for Medical Education and Research

Bo Qin

Liewei Wang

Zhenkun Lou

Matthew P Goetz

Judy C Boughey

Jia Yu

This document provides methods and materials involved in treating cancer. For example, methods and materials for using an inhibitor of USP7 polypeptide to increase the sensitivity of cancer cells (e.g., CD340cancer cells such as HER2cancer cells) to treatment with an inhibitor of a CD340 polypeptide (e.g., an inhibitor of a HER2 polypeptide) are provided. Methods and materials for using USP7 polypeptide inhibitors in combination with CD340 polypeptide inhibitors to treat cancer (e.g., HER2breast cancer that was refractory to trastuzumab alone treatment) are provided.

Methods and materials for treating cancer

This document provides methods and materials involved in treating cancer. For example, methods and materials for using an inhibitor of UFM1 activity or expression and/or an inhibitor of UFL1 activity or expression to reduce a cancer cell's ability to carry out a DDR, thereby increasing the sensitivity of cancer cells to treatment with a DNA damaging therapy such as radiation or chemotherapy, are provided.

Growing community of inventors

Rochester, MN, United States of America

Bo Qin