Ironwood Pharmaceuticals, Inc.

Bo Peng

Kevin Sprott

Ara Mermerian

Colleen Hudson

James Jia

Xiang Y Yu

Joel D Moore

Takashi Nakai

Angelika Fretzen

Timothy Claude Barden

Jason Matthew Rohde

Charles Kim

Jane Yang

Wilmin Bartolini

Regina Graul

The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1.

FAAH inhibitors

Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I: 

CRTH2 modulators

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Arlington, MA, United States of America

Bo Peng