Pure World Botanicals, Inc.

Naturex

Bo Lin Zheng

Kan He

Qun Yi Zheng

Yu Shao

Calvin Hyungchan Kim

Lingling Rogers

Stephen Wolthoff

Baoliang Cui

The invention relates to compositions that can be isolated from Lepidium plant material and to methods for their isolation. The compositions are useful for treating and preventing cancer and sexual dysfunction.

Compositions and methods for their preparation from lepidium

The present invention relates to novel imidazole alkaloid compounds that have been isolated as a form of chloride salt from a root extract ofWalp, with the common name Maca, and identified below as 1,3-bis(phenylmethyl)-4,5-dimethyl-1H-imidazlium chloride and 1,3-bis(phenylmethyl)-2,4,5-trimethyl-1H-imidazlium chloride, compounds (1) and (2), respectively.The present invention further relates to the use of these novel compounds (1) and (2) to treat proliferative diseases, such as but not limited to cancer.

Imidazole alkaloids from Lepidium meyenii and methods of usage

An isolated composition obtained by extracting roots is provided. The composition is substantially free of cellulose and comprises between about 5% and about 9% of benzyl isothiocyanate, between about 1% and about 3% of Lepidium sterol component, between about 20% and about 30% of Lepidium fatty acid component, and about 10% or more of macamide component. The composition is prepared by a process which comprises contacting Lepidium meyenii roots with a first aqueous solvent of about 90% vol-% or more water, then separating the residual root material from the first contacted aqueous solvent, then contacting the residual root material with a second aqueous solvent which comprises a mixture of an alcohol and water having about 90 vol-% alcohol or more to form a liquor, and then finally concentrating the liquor to obtain the composition. The composition can be used for treating cancer and sexual dysfunction.

Treatment of sexual dysfunction with an extract of Lepidium meyenii roots

Provided are products including trihydroxystilbenes and glycosylated derivatives thereof. Also provided are compositions containing these products with an aqueous solvent, particularly and alcohol-water mixture, and reverse phase chromatographic methods for isolating and purifying the compositions from plant materials. The products have biological activity, including anti-tumor activity.

Products comprising trihydroxystilbenes and derivatives thereof and methods for their manufacture and use

An isolated composition obtained by extracting,roots is provided. The composition is substantially free of cellulose and comprises between about 5% and about 9% of benzyl isothiocyanate, between about 1% and about 3% of Lepidium sterol component, between about 20% and about 30% of Lepidium fatty acid component, and about 10% or more of macamide component. The composition is prepared by a process which comprises contacting,roots with a first aqueous solvent of about 90% vol-% or more water, then separating the residual,root material from the first contacted aqueous solvent, then contacting the residual,root material with a second aqueous solvent which comprises a mixture of an alcohol and water having about 90 vol-% alcohol or more to form a liquor, and then finally concentrating the liquor to obtain the composition. The composition can be used for treating cancer and sexual dysfunction.

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Aurora, CO, United States of America

Bo Lin Zheng