Shanghai Microport Ep Medtech Co., Ltd.

Shanghai Zhimeng Biopharma, Inc.

Semtech Corporation

Bo Liang

Huanming Chen

Hui Wang

Lei Shen

Yiyong Sun

Gang Liu

Tao Miao

Tian Xia

William Allen Russell

Changjun Huang

Mei Wang

Lei Hua

Bo Hua

Zhijun Zhang

Qiu Jin

Pengcheng Han

Zhaohua Chang

Liuping Shen

Ziyan Zhou

Yunzhu Xi

Jiaqiang Jiang

Jiahong Tan

Qiancheng Zhao

2-aminopyrimidine compounds and pharmaceutical compositions and uses thereof are provided. Specifically, the 2-aminopyrimidine compounds have a structure as shown in formula I. The compounds are suitable for use in the fields of anti-virus and anti-infection, as well as treatment of diseases such as autoimmune diseases and tumors.

2-aminopyrimidine compounds and pharmaceutical compositions and uses thereof

Disclosed are a compound having a neuroprotective effect, a preparation method therefor and a use thereof. Specifically, the compound has the structure shown by formula I, the definition of each group and substituent being as described in the description. Further disclosed are a preparation method for the compound and a use thereof for neuroprotection.

Compound having neuroprotective effect, preparation method therefor and use thereof

A strain gauge (), a pressure sensor (), and an interventional medical catheter. The strain gauge () comprises a substrate () and at least two sensitive gages () provided on the substrate (), the at least two sensitive gages () being arranged along two mutually perpendicular directions and sharing one ground port (). The pressure sensor () comprises an elastic body () and the strain gauge () provided on the elastic body (). The interventional medical catheter comprises a catheter distal end and the pressure sensor () provided at the catheter distal end. The present application not only saves the trace space for mounting and using the strain gauge () on the interventional medical catheter, facilitating the successful mounting and use of the strain gauge () on the interventional medical catheter, improving the adaptability of the strain gauge (), but also reduces the size of the strain gauge (), thereby shortening the length of the elastic body () of the pressure sensor () and reducing the size of the interventional medical catheter.

Strain gauge, pressure sensor, and interventional medical catheter

A semiconductor device includes a voltage input circuit node and a ground voltage node. A first transistor is coupled between the voltage input circuit node and the ground voltage node. A triggering circuit is coupled between the voltage input circuit node and the ground voltage node in parallel with the first transistor. The triggering circuit includes a trigger diode. An output of the triggering circuit is coupled to a control terminal of the first transistor. A load is powered by coupling the load between the voltage input circuit node and the ground voltage node.

Protection circuit with a FET device coupled from a protected bus to ground

A balloon catheter () and an electrophysiological system, which aim to improve the operability of accurately monitoring the balloon surface temperature at the surface of a double-layered balloon (). The balloon catheter () comprises a catheter body (), a double-layered balloon (), at least one temperature measuring element (), and at least one adhesion piece (); the temperature measuring element () is disposed in an interlayer () formed by an inner layer balloon () and an outer layer balloon (); the adhesion piece () is adheringly connected to the temperature measuring element (), and is simultaneously adheringly connected to the inner layer balloon () or the outer layer balloon (); the temperature measuring element () is attached to the inner layer balloon () or the outer layer balloon () by means of the adhesion piece (); when the double-layered balloon () is deformed, the adhesion piece () may be displaced relative to the inner layer balloon () or outer layer balloon () connected to the adhesion piece (), which enables the temperature measuring element () to be displaced relative to the inner layer balloon () or outer layer balloon () connected to the adhesion piece ().

Balloon catheter and electrophysiological system

A compound as a potassium channel regulator and preparation and use thereof are described. Specifically, the compound has the structure shown in formula A. A preparation method of the compound and its use as a potassium channel regulator in a medicament and a pharmaceutical composition are also described.

Compound as potassium channel regulator and preparation and use thereof

An electrophysiological catheter and an ablation system comprising a control device, an ablation energy output device and the electrophysiological catheter. The control device controls the ablation energy output device to selectively provide a first fluid or a second fluid that is a frozen liquid to the electrophysiological catheter. When the ablation energy output device provides the first fluid, the control device controls a first heating component on the electrophysiological catheter to work to heat the fluid entering the electrophysiological catheter for spraying a thermal ablation gas onto the inner surface of a balloon; and when the ablation energy output device provides frozen liquid, the control device controls the first heating component not to work to directly spray the frozen liquid to the inner surface of the balloon.

Balloon catheter and ablation system

p-phenylenediamine derivatives as potassium channel regulators and preparation methods and medical application thereof. A compound represented by general formula A or a pharmaceutically acceptable salt thereof. A preparation method of the compound and a use of the same as a potassium channel opener.

P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof

A strain gauge includes: a substrate; a transverse sensitive grid arranged on the substrate; and at least two non-transverse sensitive grids arranged on the substrate so as to be located on opposite sides of the transverse sensitive grid both electrically connected to the transverse sensitive grid. The two non-transverse sensitive grids are connected to each other by a connection and share a common ground lead and a common ground interface. One end of the ground lead is connected to the connection at the middle thereof. The other end of the ground lead is connected to the ground interface. The two non-transverse sensitive grids have equal resistances and are connected to ends of two respective non-ground leads having equal resistances. The other ends of the two non-ground leads are connected to two respective non-ground interfaces.

Strain gauge, force sensor and interventional medical catheter

A strain gauge (), a pressure sensor (), and an interventional medical catheter. The strain gauge () comprises a substrate () and at least two sensitive gages () provided on the substrate (), the at least two sensitive gages () being arranged along two mutually perpendicular directions and sharing one ground port (). The pressure sensor () comprises an elastomer () and the strain gauge () provided on the elastomer (). The interventional medical catheter comprises a catheter distal end and the pressure sensor () provided at the catheter distal end. The present application not only saves the trace space for mounting and using the strain gauge () on the interventional medical catheter, facilitating the successful mounting and use of the strain gauge () on the interventional medical catheter, improving the adaptability of the strain gauge (), but also reduces the size of the strain gauge (), thereby shortening the length of the elastomer () of the pressure sensor () and reducing the size of the interventional medical catheter.

p-phenylenediamine derivatives as potassium channel regulators and preparation methods and medical applications thereof. A compound represented by general formula A or a pharmaceutically acceptable salt thereof. A preparation method of the compound and a use of the same as a potassium channel opener.

An electrophysiology catheter () includes a catheter distal portion () on which a force sensor () is arranged. The force sensor () includes an elastic tube () and strain gauges (). The elastic tube () has a hollow portion in its wall, and the strain gauges () are disposed external to the hollow portion. Compared to the design with the strain gauges () overlapping the hollow portion, arranging them over solid portions of the elastic tube () allows the strain gauges () to collect more accurate electrical signals while suffering from less interference. This can result in a significant improvement in contact force measurement accuracy of the catheter distal portion ().

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Shanghai, China

Bo Liang