Aktiebolaget Leo

Bo Fredholm

Hans Jacob Fex

Bertil Hogberg

Torsten Rune Perklev

Sten Gunnar Veige

This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith. The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3',5'-monophosphate (cyclic AMP). In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.

Novel compounds, compositions containing such compounds, processes for

Method, composition and compounds for treating excess prostaglandins

Secondary phosphoric acid esters, composition and method of use

This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith. The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3' ,5'-monophosphate (cyclic AMP). In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.

Secondary phosphoric acid esters

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Nyhamnslage, Sweden

Bo Fredholm