Agency for Science, Technology and Research

Bo Feng

Huck Hui Ng

Na Yu Chia

Thomas Lufkin

Petra Kraus

Jianming Jiang

Methods of inducing pluripotency in human somatic cells and methods of maintaining pluripotency in human embryonic stem cells (hESCs) are provided, as well as cells and uses of employing such cells. The methods comprise culturing cells in the presence of (i) OCT4 and SOX2; (ii) at least one of KLF4 and c-MYC; and at least one of PRDM14 and NFRKB.

Method for inducing pluripotency in human somatic cells with PRDM14 or NFRKB

The invention provides a method of effecting de-differentiation of an at least partially differentiated cell or of maintaining pluripotency and/or self-renewing characteristics of an undifferentiated cell. The method comprises increasing the amount or the activity of an Err protein, or a functional fragment thereof, in the cell.

Growing community of inventors

Singapore, Singapore

Bo Feng