Civitas Therapeutics, Inc.

Alkermes, Inc.

Advanced Inhalation Research, Inc.

Blair C Jackson

Raymond T Bartus

Dwaine F Emerich

David J Bennett

Richard P Batycky

Charles D Blizzard

Jean C Sung

Lloyd Johnston

Jeffrey Mintzes

Ernest E Penachio

Marie Elizabeth Chung

Raymond T Bartas

Jeffrey D Mintzes

Lloyd P Johnston

In one aspect, the invention is related to a method of treating a patient with Parkinson's disease, the method including administering to the respiratory tract of the patient particles that include more than about 90 weight percent (wt %) of levodopa. The particles are delivered to the patient's pulmonary system, preferably to the alveoli or the deep lung.

Pulmonary delivery for levodopa

Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention optimizes process conditions for increasing and controlling particle porosity. The present invention also allows for optimization of particle size in real-time during particle production.

Method and apparatus for producing dry particles

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South Grafton, MA, United States of America

Blair C Jackson