Alligator Bioscience Ab

Pergamum Ab

Follicum Ab

Dermagen Ab

Ximmune Ab

Björn Walse

Margit Mahlapuu

Artur Schmidtchen

Veronika Sjöstrand

Marie Asa Ingegerd Karlsson

Camilla Björn

Bo Svenson

Mats Peter Anderson

Eva Maria Dahlén

Patrick Thomas Höjman

Christina Furebring

Cecilia Ann-Christin Malmborg Hager

Jan Alenfall

Martin Malmsten

Gopinath Kasetty

Martina Kalle

Pontus Dunér

Praveen Papareddy

Karin Haraldsson

Nils Martin Malmsten

Anna Rosén

Erika Gustafsson

Anna Hultgårdh Nilsson

Cecilia Ann-Christin Malmborg Hanger

Karin Elisabeth Barchan

Karin Elisabeth Brachan

Veronika SJÖSTRAND

Bo Svensson

The present disclosure concerns agents and their use in the treatment of endocrine, nutritional and/or metabolic diseases in a mammal. The disclosure furthermore concerns novel peptides.

Peptides for treatment of diabetes

The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from a naturally occurring protein which modulates blood coagulation, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant or derivative thereof, for use in the treatment or prevention of inflammation and/or excessive coagulation of the blood. Related aspects of the invention provide isolated polypeptides comprising or consisting of an amino acid sequence of SEQ ID NOS: 1 to 3, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant or derivative thereof, which exhibit an anti-inflammatory activity, together with isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of inflammation and/or excessive coagulation.

Heparin cofactor II fragments with anti-inflammatory and anti-coagulant activity

The invention provides an isolated polypeptide comprising a variant amino acid sequence of SEQ ID NO: 1, or a fusion or derivative of said polypeptide, or a fusion of a said derivative thereof, wherein the polypeptide, fusion or derivative retains a biological activity of wild type IL-IRa. In one embodiment, the isolated polypeptide, fusion or derivative is or comprises a polypeptide variant of amino acid sequence SEQ ID NO: 1 comprising or consisting of substitutions at one or more of the following amino acid mutations of SEQ ID NO: 1: Q29K, P38Y, P38R, L42W, D47N, E52R, H54R, E90Y, Q129L, Q129N, M136N, M136D and Q149K. Also provided are pharmaceutical compositions of the above polypeptide, fusion or derivative, as well as uses of the same for treating a disease or condition capable of being treated by an agent which inhibits the function of IL-1 receptors.

Mutants of interleukin-1 receptor antagonist

The present invention relates to new peptides and to use thereof, in particular for treatment and/or prevention of infections, inflammations, pain, wounds, scar and/or tumors.

Synthetic peptides and their use

Human lactoferrin derived peptides and their use

The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of('CHIPS'), the polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 2, or a fragment or variant thereof having a biological activity of CHIPS, wherein the fragment or variant retains amino acid substitutions K40E, D42V, N77H, K100R, K105R, N111 K and/or G112A relative to the wildtype CHIPS protein of SEQ ID NO:1. In one embodiment, polypeptide consists of the amino acid sequence of SEQ ID NO: 2. Related aspects of the invention provide pharmaceutical compositions comprising a polypeptide of the invention, together with methods or making and using the same.

Polypeptides and use thereof

The invention relates to a molecule comprising at least the amino acid sequence XXXXXXW XXXwherein Xis any amino acid residue, Xis I, L or V, Xis not C, Xis A, E, Q, R or Y, Xis not R, Xis I or L, Xis not H and wherein said molecule have a length of from about 10 to about 100 amino acid residues or an analogue thereof. The invention also relates to compositions comprising said molecule and use of the molecule and/or composition of the invention to combat microorganisms, such as bacteria, viruses, fungi, including yeast, and parasites.

Antimicrobial peptides and use thereof

Growing community of inventors

Lund, Sweden

Björn Walse