Ecole Polytechnique Federale De Lausanne

Universitè De Genève

Nano Bridging Molecules Sa

Ecole Polytechnique Féderale De Lausanne (epfl)

Björn-Owe Aronsson

Pierre Descouts

Peter Péchy

Michael Grätzel

Carine Viornery

Michael Gratzel

Péter Péchy

Sabrina Buchini

Richard Curno

Carine Viorney

Michael GRÄTZEL

The present invention relates to a process of treating an implant, comprising a step of treating the surface of the implant with at least one phosphonic acid compound or a pharmaceutically acceptable salt, ester or amide thereof under sonication at a temperature of about 50&#xb0; C. to about 90&#xb0; C. This process is highly advantageous in that it allows the formation of a monolayer of the phosphonic acid compound on the implant surface, having a particularly dense surface coverage which, in turn, results in an improved implant biocompatibility and improved osseointegration. The invention further relates to a surface-treated implant obtainable by this process and, in particular, it provides an implant having a surface made of a metal, a metal alloy or a ceramic, wherein a phosphonic acid compound or a pharmaceutically acceptable salt, ester or amide thereof is bound to the surface of the implant and forms a monolayer having an implant surface coverage, in terms of the ratio of the phosphorus content to the metal content as determined by X-ray photoelectron spectroscopy (XPS), of at least 70% of a reference maximum surface coverage.

Treatment of implants with phosphonic acid compounds

Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.

Endosseous implant

Endosseous implant to be applied to human or animal bone, said implant having a surface made from a selected metal or a selected metal alloy or a ceramic, whereby said metal resp. metal alloy is selected from chromium, niobium, tantalum, vanadium, zirconium, aluminium, cobalt, nickel, stainless steels or an alloy thereof, said surface having a smooth or rough texture, characterized in that said surface has been treated with at least one pharmaceutically acceptable organic compound carrying at least one phosphonic acid group or a derivative thereof preferably a pharmaceutically acceptable salt or ester or amid thereof and method for producing said implant.

Growing community of inventors

Veyrier, Switzerland

Björn-Owe Aronsson