Merck Sharp + Dohme Corp.

Bjorn Victor

Robert A Kastelein

Marie-Ange Buyse

Carlo Boutton

Juha Punnonen

Bruno Dombrecht

Maribel Beaumont

Edward P Bowman

David Vlerick

The present invention provides molecules, such as ISVDs and Nanobodies, that bind to CTLA4 or human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.

CTLA4 binders

The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.

PD1/CTLA4 binders

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Zwijndrecht, Belgium

Bjorn Victor