Rousselot B.v

Bjorn Vergauwen

Paul Stevens

Joseph Hubertus Olijve

Elke De Clerck

Guy Van De Mooter

The present invention relates to methacryloyl-gelatin and acryloyl-gelatin with low pyrogenic activity, in particular with low lipopolysaccharide content. The (meth)acryloyl-gelatin is further characterized by low (meth)acrylic acid content. The invention further relates to methods for preparing said (meth)acryloyl-gelatin, which do not require a dialysis step. The invention further relates to hydrogels comprising this (meth)acryloyl-gelatin, as well as uses thereof for tissue-engineering applications, and as bio-ink or bio-resin.

Low endotoxin gelatin-(meth)acryloyl

Described is an improved method of removing lipopolysaccharide from an aqueous medium comprising gelatin and lipopolysaccharides, the method comprising the steps of providing an aqueous medium comprising gelatin and lipopolysaccharides, adding to the aqueous medium a micelle-forming surfactant, contacting the medium with a solid adsorbent, separating the solid adsorbent of from the medium and recovering the aqueous medium comprising the gelatin, wherein the method is performed at conditions below the cloud point of the surfactant.

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Lokeren, Belgium

Bjorn Vergauwen