Medivir Ab

Astra Lakemedel Aktiebolag

Bjorn G Lindborg

Karl N Johansson

Xiao-Xiong Zhou

Nils-Gunnar Johansson

Per Engelhardt

Marita Hogberg

Roelf Datema

Goran B Stening

Bo F Oberg

Zsuzsanna M Kovacs

Zsuzanna M Kovacs

Bo F Berg

M Robert Leanna

Michael Rasmussen

Kristina B Gotthammar

Jan-Olof Noren

Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: 

Acyclic nucleoside derivatives

Compounds of the Formula I ##STR1## where one of R.sub.1 and R.sub.2 is --C(O)CH(CH(CH.sub.3).sub.2)NH.sub.2 or --C(O)CH(CH(CH.sub.3)CH.sub.2 CH.sub.3)NH.sub.2;

Antivirally active compounds of formula (I), wherein R.sup.1 is hydrogen, hydroxy, mercapto or amino; R.sup.2 is hydrogen, hydroxy, fluoro, chloro or amino; R.sup.3 and R.sup.4 are independently selected from (II), (III), amino, hydroxy or an ether or ester residue thereof, or R.sup.3 together with R.sup.4 is (IV), wherein M is hydrogen or a pharmaceutically acceptable counterion; and n is 1 or 2; with the proviso that, when R.sup.2 is amino and R.sup.3 and R.sup.4 are hydroxy, R.sup.1 is not hydroxy and in addition, when n=1, R.sup.1 is not hydrogen, and pharmaceutically acceptable salts thereof; processes for preparation of said compounds, a pharmaceutical composition comprising said compounds, methods for treatments of virus infections as well as use of compounds of formula (I) without the proviso for the manufacture of a medicament for treatment of AIDS. ##STR1##

Derivatives of purine, process for their preparation and a

A compound of the formula ##STR1## wherein the radicals A, X, R.sup.1, R.sup.2 and R.sup.3 are defined as follows:

.alpha. nucleoside compounds and a method for treating HBV using said

Use of a compound of the formula ##STR1## wherein A is .beta.-2'-deoxy-D-ribofuranosyl or .beta.-D-arabinofuranosyl;

Antiviral pharmaceutical composition comprising 5-substituted pyrimidine

A compound of the formula ##STR1## wherein the radicals A, X, R.sup.1, R.sup.2 and R.sup.3 are defined as follows: ##STR2## R.sup.2 : H; or R.sup.2 constitutes together with R.sup.3 with a carbon - carbon bond

Nucleosides and nucleotide analogues, pharmaceutical composition and

Antivirally active compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxymethyl;

Derivatives of purine

Antivirally active compounds of the formula ##STR1## wherein A is ##STR2## wherein m is 1 or 2,

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Alvsjo, Sweden

Bjorn G Lindborg