La Jolla Institute for Allergy and Immunology

Alk-abello A/s

Alk-AbellÓ, Inc.

Bjoern Peters

Alessandro D Sette

Howard M Grey

Jason Greenbaum

John Sidney

Sonia Sharma

Gitte Lund

Lise Lund Mærkedahl

Peter Adler Würtzen

Lars Harder Christensen

Claus Lundegaard

Cecilia Lindestam Arlehamn

Carla Oseroff

Pandurangan Vijayanand

Shashank Gupta

Cecilia Arlehamm

Greg Seumois

Jens Brimnes

Helene Henmar

Thomas Stranzl

Susanne Sønderkær

Thomas Christian Mygind

Veronique Schulten

The specificity of CD4+ TH responses of German cockroach (Bla g) antigens, and whether differences exist in magnitude or functionality as a function of disease severity, is disclosed. Also disclosed are novel German cockroach allergens and epitopes.

Antigens and T cell epitopes from cockroach and methods of making and using same

The invention provides Cockroach proteins, peptides, subsequences, portions, homologues, variants and derivatives thereof, and methods and uses and medicaments of such proteins, peptides, subsequences, portions, homologues, variants and derivatives thereof. Such methods, uses and medicaments include modulating an immune response, protecting a subject against or treating a subject for an allergic response, allergic disorder or allergic disease and inducing immunological tolerance to the allergen (e.g., Cockroach allergen) in a subject.

T cell epitopes from Cockroach and methods of making and using same

The invention relates to combinations of peptides derived from a portion of an amino sequence of a grass pollen allergen, e.g. the allergens Phl p 1, Phl p 2, Phl p 3, Phl p 4 and/or Phl p 5, or a peptide variant thereof. Such peptides comprise at least one T cell epitope mid a high number of patients in a worldwide population will have HLA Class II alleles with the potential to bind the peptides of the peptide combinations. The invention also relates to the use of such peptide combinations in relieving an immune response caused by grass pollen species.

Peptide combinations and uses thereof for treating grass allergy

The invention relates to common allergen proteins and peptides, subsequences, portions, homologues, variants and derivatives thereof, and methods and uses of common allergen proteins and peptides. Methods include, for example, modulating an immune response; protecting a subject against or treating a subject for an allergic response, allergic disorder or allergic disease; and inducing immunological tolerance to the allergen in a subject.

Epitopes from allergen proteins and methods and uses for immune response modulation

The present invention relates toproteins and peptides, and subsequences, portions or modifications thereof and methods and compounds comprising the same for eliciting, stimulating, inducing, promoting, increasing, or enhancing an anti-immune response in a subject.

Antigens and epitopes derived from

The invention relates to novel immunogenic polypeptides identified in house dust mites and storage mites, which have the potential to be used in allergy immunotherapy, for diagnostic purposes, eventually via production of antibodies binding the polypeptide or for characterising allergen extracts of house dust mites and storage mites.

Immunogenic proteins and fragments thereof from allergenic mites

The invention relates to Timothy Grass proteins and peptides, subsequences, portions, homologs, variants and derivatives thereof, and methods and uses of Timothy Grass proteins and peptides. Methods include, for example, modulating an immune response; protecting a subject against or treating a subject for an allergic response, allergic disorder or allergic disease; and inducing immunological tolerance to the allergen in a subject.

Timothy grass allergens and methods and uses for immune response modulation

The invention relates to novel targets for immune response modulation, treatment of tuberculosis infection and epitopes of, or subsequences, portions or modifications thereof, and methods and compounds for treatment and prevention of tuberculosis infection.

Specific and unique T cell responses and molecular signatures for the treatment and diagnosis of

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La Jolla, CA, United States of America

Bjoern Peters