Rheinische Friedrich-wilhelms-universitat Bonn

Life & Brain Gmbh

Rheinische Friedrich-wilhelms-universität

Björn Scheffler

Martin Glas

Anja Wieland

Matthias Simon

Oliver Brüstle

Ulrich Johannes Herrlinger

Sabine Gogolok

Daniel Trageser

Roman Reinartz

The present invention relates to novel therapeutic uses of niclosamide for the treatment of cancer. In particular, a combination of niclosamide or one of its derivatives with an alkylating agent is provided for the treatment of solid tumors. Moreover, niclosamide or one of its derivatives can be used for the treatment of solid tumors characterized by underexpression of NFKBIA. Finally, the invention relates to diagnostic methods for determining whether treatment with niclosamide alone or in combination with an alkylating agent is suitable for a cancer patient.

Niclosamide and its derivatives for use in the treatment of solid tumors

The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma. Moreover, methods for determining whether a treatment with the compounds of the invention is suitable for a patient are disclosed.

Glioblastoma inhibiting compounds and their use

The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.

Peripheral zone tumor cells, methods for their preparation and use

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Bonn, Germany

Björn Scheffler