Queen Mary & Westfield College

Watchmaker Genomics, Inc.

Bjarne Faurholm

Yuti Chernajovsky

Brian Kudlow

David Perrett

Paul Graham Winyard

Francesco Dell'Accio

Ross Wadsworth

Ahuva Nissim

Julie Walker

Christopher Hughes

Stephen Mather

Paul Winyard

The present invention provides MMLV reverse transcriptase enzymes with increased thermal stability as compared with wild type MMLV and AMV reverse transcriptases. The improved thermal stability allows for reverse transcription of RNA to cDNA at temperatures above 37&#xb0; C., thereby reducing error rates introduced during cDNA synthesis. As a result, the reverse transcriptases of the invention allow for increased accuracy in the determination of transcriptomes of living organisms.

Reverse transcriptase variants

The present invention provides a composition comprising an antibody or fragment thereof against oxidized Collagen II (CII) in which the antibody or fragment thereof is conjugated to a pharmaceutically active moiety. The invention also provides a composition comprising an antibody or fragment thereof against oxidized Collagen II (Gil) and a detectable label. The invention further provides the use of such compositions in medicine, in particular for the treatment of an arthropathy, and in methods of diagnosis.

Antibody and use in diagnosis and therapy of arthropathies

Growing community of inventors

Cape Town, South Africa

Bjarne Faurholm