Celgene Corporation

Anthrogenesis Corporation

Clarity Acquisition Ii LLC

Bitao Liang

Stewart Abbot

Tianjian Li

Wei Liu

James W Edinger

Xiaokui Zhang

Steven Alan Fischkoff

Aleksandar Francki

Vladimir Jankovic

Cynthia Ray

Philippe Martin

Christopher Wiwi

Kathy E Karasciewicz-Mendez

Xiaohua Lu

Kruti Shah

Provided herein are methods of generating T cells, e.g., cytotoxic T lymphocytes starting from peripheral blood mononuclear cells without a separate step of generating and isolating antigen-presenting cells, and with a single round of antigen stimulation. Also provided herein are methods of using said cytotoxic T lymphocytes, for example, to treat cancer and/or viral infection.

T lymphocyte production methods and t lymphocytes produced thereby

Provided herein are cells, e.g., T cells expressing artificial cell death polypeptides that cause death of a cell, e.g., cells (e.g., T lymphocytes) expressing the cell death polypeptide, when the cell death polypeptide is multimerized or dimerized. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.

Modified T lymphocytes comprising a CD52 antibody-inducible caspase and methods of apoptosis

Provided herein are methods for enhancing the transduction efficiency of vectors into cells, e.g., primary human T lymphocytes.

Methods of improving vector transduction efficiency into T lymphocytes

Provided herein are therapeutic polypeptides, e.g., chimeric antigen receptors, able to direct an immune cell, e.g., a T lymphocyte to a target antigen, and able to cause the T cell to proliferate or to kill cells displaying the antigen when the antigen binds to the polypeptide, wherein the polypeptides comprise a transmembrane domain from a T cell co-inhibitory protein such as CTLA4 or PD-1. Also provided herein are T lymphocytes expressing the polypeptides, and use of such T lymphocytes to treat diseases such as cancer.

Chimeric antigen receptors

Modified T lymphocytes comprising a BAFF antibody-inducible caspase and methods of apoptosis

Modified T lymphocytes comprising an inducible caspase and methods of apoptosis

Methods of treating individuals having sarcoidosis or a sarcoidosis-related disease or disorder using placental cells are described. Also describe are kits comprising placental stem cells or a composition thereof that can be used in methods of treating sarcoidosis or a sarcoidosis-related disease or disorder.

Treatment of sarcoidosis using placental stem cells

Growing community of inventors

Closter, NJ, United States of America

Bitao Liang