Sun Pharma Advanced Research Company Limited

Bioprojet

Biswajit Samanta

Jayraj Dilipbhai Aradhye

Bhavesh Mohanbhai Panchal

Jean-Charles Schwartz

Jeanne-Marie Lecomte

Rajamannar Thennati

Marc Capet

Philippe Robert

Isabelle Berrebi-Bertrand

Ranjan Kumar Pal

Muthukumaran Natarajan Pillai

Trinadha Rao Chitturi

Nicolas Levoin

Thennati Rajamannar

Kilaru Srinivasu

Sandeep Pankajbhai Pathak

Japan Nitinkumar Desai

Sandeep Pankajkumar Pathak

Anil Kumbhani

Kaushik Dhanjibhai Prajapati

Dijixa Chandubhai Rana

Kaushik Dhanjubhai Prajapati

Jignesh Kantilal Jivani

Rajan Kumar Pal

Bhavesh M Panchal

Jayraj D Aradhye

A selective estrogen receptor degrader (SERD), a compound 3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, and its S enantiomer, (2S)-3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, or pharmaceutically acceptable salts thereof. Also provided are processes for their preparation. Also provided for is the use of these compounds for the treatment of diseases which are related to modulation of estrogen receptors, such as ER-positive breast cancer.

Selective estrogen receptor degrader

The present invention relates to novel carbamate intermediate of formula (II), process for its preparation and process for its conversion into 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol, tapentadol and its pharmaceutically acceptable salts. 

Intermediate of tapentadol

The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation. 

Piperidinyl monocarboxylic acids as S1P1 receptor agonists

The present invention relates to new compounds of formula (I) possessing agonistic activity at sphingosine-1-phosphate (S1P) receptors, their process of preparation and their use as immunosuppressive agents. The invention is also directed to pharmaceutical compositions containing these compounds and use of these compounds for treatment/prevention of immune mediated diseases and conditions or inflammatory diseases and conditions.

Dicarboxylic acid derivatives as S1P1 receptor agonists

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Vadodara, India

Biswajit Samanta