Ranbaxy Laboratories, Inc.

Daiichi Sankyo Company, Limited

Biswajit Das

Ashok Rattan

Sonali Rudra

Anita Mehta

Abhijit Ray

Rita Katoch

Dilip J Upadhyay

Masao Itoh

Sudershan Kumar Arora

Hiroaki Inagaki

Mohammad Salman

Tetsunori Fujisawa

Saito Higuchi

Aki Yokomizo

Toshifumi Tsuda

Jasbir Singh Arora

Shahadat Ahmed

Anish Bandyopadhyay

Santosh Haribhau Kurhade

Sujata Rathy

Soma Ghosh

Abhijit Datta Khoje

Arti Gujrati

Sangita Sangita

Arora K Sudershan

A compound represented by the following formula (I) or a salt thereof:   

Amino group-containing pyrrolidinone derivative

Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example,or Enterobactericeae, and fungal organisms, for example,, or. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.

Antimicrobial agents

Provided herein are novel substituted phenyl oxazolidinones and to processes for the synthesis thereof. Also provided are pharmaceutical compositions comprising one or more compounds described herein The compounds described can be useful antimicrobial agents, which can be effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci, as well as, anaerobic organisms, such asspp. andspp. species, and acid fast organisms, such asandspp.

Oxazolidinone derivatives as antimicrobials

The present invention relates to certain substituted phenyl piperazinyl oxazolidinones, for example, to those having the structure of Formula Iwith the variables as defined within, and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such asspp. andspp. species, and acid fast organisms such asandspp.

Oxazolidinone piperazinyl derivatives as potential antimicrobials

The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as and Mycobacterium spp.

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Haryana, India

Biswajit Das