Evonik Goldschmidt Corporation

Novozymes Biopolymer A/s

Evonik Degussa Gmbh

Birgitte Moelholm Malle

Mike Farwick

Hans Henning Wenk

Ursula Maczkiewitz

Sandra Nattland

The present invention relates to methods of producing crosslinked hyaluronic acid microbeads, as well as the produced microbeads, said method comprising the steps of: (a) providing an aqueous alkaline solution comprising hyaluronic acid, or a salt thereof; (b) forming microdroplets having a desired size from the mixed solution of step (a) in an organic or oil phase to form a water in organic or water in oil (VWO) emulsion, wherein the amount of oil phase used is of from 20 to less than 50% by weight based on the sum of oil phase and water; (c) adding a solution comprising a crosslinking agent to the emulsion, whereby the reaction of hyaluronic acid with the crosslinking agent takes place to provide crosslinked hyaluronic acid microbeads; and (d) optionally working up the dispersion of crosslinked hyaluronic acid microbeads obtained in step (c).

Growing community of inventors

Birkeroed, Denmark

Birgitte Moelholm Malle