Ludwig Institute for Cancer Research Limited

Other

Helsinki University Licensing Ltd. Oy

Licentia, Ltd.

Birgitta Olofsson

Kari Alitalo

Ulf Eriksson

Katri Pajusola

Taija Makinen

VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.

Processed vascular endothelial growth factor-B polypeptides

Complexes of a protein selected from the group consisting of VEGF-B , VEGF-C, VEGF-D and processed VEGF-B and analogs thereof and the neuropilin-1 (NP-1) receptor, the extracellular domain or a ligand-binding fragment or analogue thereof; the use of such complexes in assays for growth factor proteins having substantially the same binding affinity for a cell surface receptor as VEGF-B , VEGF-C, VEGF-D or processed VEGF-B and/or in promoting or antagonizing a cellular response mediated by VEGF-B , VEGF-C, VEGF-D and/or processed VEGF-B ; and specific binding partners, e.g. antibodies, for such complexes.

Neuropilin/growth factor complexes and uses thereof

Antibodies specific for vascular endothelial growth factor-B

Vascular endothelial growth factor-b and dna coding therefor

Vascular endothelial growth factor-B

Vascular endothelial growth factor-B and DNA coding therefor

Growing community of inventors

Stockholm, Sweden

Birgitta Olofsson