Merck Patent Gmbh

Danisco US Inc.

Danisco A/s

Dupont Nutrition Biosciences Aps

Direvo Industrial Biotechnology Gmbh

Danisco US Inc., Genencor Division

Marck Patent Gmbh

Basf Se Corporation

Birgitta Leuthner

Christos Tsaklakidis

Oliver Kensch

Wolfgang Staehle

Ulrich Kettling

Andrei Miasnikov

Vijay Kumar

Andre Koltermann

Hans-Peter Buchstaller

Jayarama K Shetty

Michael Jay Pepsin

Christina Esdar

Thomas Fuchss

Dirk Wienke

Mai Faurschou Isaksen

Klaus Pellangahr

Klaus Schulze Pellengahr

Klaus Pellengahr

Dieter Dorsch

Michael C Ward

Michael D Ward

Markus Klein

Marguerite A Cervin

Hans Guehring

Ulrich Haupts

Paul Czodrowski

Ansgar Wegener

Manja Friese-Hamim

Steven Sungin Kim

Andreas Scheidig

Steve Sungjin Kim

Nadine Koch

Wayne M Coco

Soeren Dalsgaard

Markus Rarbach

Ute Beister

Søren Dalsgaard

Frank Czauderna

Ute Solloch

Wayne Coco

Steve Kim

Chirstina Esdar

Soren Dalsgaard

3-substituted cyclopentylamine derivatives

Provided herein are variants ofsp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.

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The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.

Aminostatin derivatives for the treatment of arthrosis

Compounds of the formula I in which R, X, X, X, X, R, Rand q have the meanings indicated in Claimare inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Piperazine derivatives as FASN inhibitors

Compounds of the formula I in which R, W, R, R, X, X, X, Xand q have the meanings indicated in claimare inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Compounds of the formula I in which R, X and n have the meanings indicated in Claim, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Phthalazine derivatives

Compounds of the formula I in which R, Y, R, X, X, Xand q have the meanings indicated in claim, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

1,3-Disubstituted cyclopentane derivatives

Compounds of the formula I in which R, R, R, R, X, X, X, X, q and W have the meanings indicated in claimare inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

1,3-diaminocyclopentane carboxamide derivatives

Compounds of the formula I in which R, R, R, X, X, X, X, n1, n2, n3 and n4 have the meanings indicated in claim are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. 

Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitors

Compounds of the formula I in which U, V and W have the meanings indicated in Claim, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Tetrahydro-quinazolinone derivatives as TANK and PARP inhibitors

The present invention relates to enzymes and processes. In particular, there is described an isolated polypeptide comprising the amino acid sequence corresponding tophytase or a homologue, a modified form, a functional equivalent or an effective fragment thereof. There is also described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme or a modified form as well as the use of such a phytase or modified form in food or animal feed.

Mutant citrobacter freundii phytase polypeptide

The present invention relates to variant phytase enzymes having altered properties.

The present invention relates to enzymes and processes. In particular, there is described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme and variants thereof.

Enzymes

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Darmstadt, Germany

Birgitta Leuthner