Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Birgit Masjost

Wolfgang Schaefer

Stefan Scheiblich

Konrad Honold

Klaus Kaluza

Petra Rueger

Richard Engh

Manfred Schwaiger

Hubert Hertenberger

Walter-Gunar Friebe

Ralf Schumacher

Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Heterocyclic carbamate derivatives, their manufacture and use as pharmaceutical agents

The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I). 

Amide derivatives of 3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents

Benzamide derivatives, their manufacture and use as pharmaceutical agents

The present invention relates to novel amide derivatives of 7-amino-3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I). 

Amide derivatives of 7-amino-3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents

This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula (I)wherein the symbols are defined in the specification, as well as processes for their manufacture. The compounds according to this invention possess anti-cell proliferation activity and show an increased plasma-stability.

Azepane derivatives

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Basel, Switzerland

Birgit Masjost