Probiodrug Ag

Birgit Koch

Stephan Schilling

Jens-Ulrich Rahfeld

Michael Wermann

Christoph Parthier

Milton T Stubbs

David Ruiz-Carillo

Hans-Ulrich Demuth

Holger Cynis

Anett Stephan

Sigrid Graubner

Reinhard Sedlmeier

Milton Stubbs

A knock-out non-human animal, in particular a mouse, carrying a QPCTL knock-out mutation. Additionally, respective cells and cell lines and methods and compositions for evaluating agents that affect QPCTL, for use in compositions for the treatment of QPCTL-related diseases are disclosed.

Mouse models carrying a knock-out mutation of the QPCTL-gene

Novel crystal structures of human and murine glutaminyl cyclase (QC, EC 2.3.2.5), methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of human and murine glutaminyl cyclase.

Crystal structure of glutaminyl cyclase

A novel crystal structures of human and murine glutaminyl cyclase (QC, EC 2.3.2.5), methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of human and murine glutaminyl cyclase.

Growing community of inventors

Amsdorf, Germany

Birgit Koch