Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Birgit Klapperich

Johann Karl

Andrea Horsch

Dirk Block

Ursula-Henrike Wienhues-Thelen

Alfred Engel

Rosemarie Kientsch-Engel

Edelgard Anna Kaiser

Monika Soukupova

Peter Kastner

Sandra Rutz

Ekaterina Manuilova

Christina Rabe

Anna Edelgard Kaiser

The present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) during or after a surgical procedure or after administration of a contrast medium. The method is based on the determination of the level of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) in a body fluid sample obtained from the patient prior to the surgical procedure or prior to the administration of a contrast medium. Further, the present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) based on the determination of the amount of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) and Cystatin C in a body fluid sample obtained from the patient. The present disclosure further encompasses kits and devices adapted to carry out the methods of the disclosed methods.

IGFBP7 for prediction of risk of AKI when measured prior to surgery

Growing community of inventors

Risch, Switzerland

Birgit Klapperich