Basf Se Corporation

Birgit Gockel

Sebastian Soergel

Daniel Saelinger

Michael Rack

Martin John McLaughlin

Karsten Koerber

Roland Goetz

Wolfgang Von Deyn

Devendra Vyas

Joachim Gebhardt

Jochen Dietz

Arun Narine

Pascal Bindschaedler

Eric George Klauber

Joaquim Henrique Teles

Deborah L Culbertson

Volker Maywald

Joachim Dickhaut

Egon Haden

Henricus Maria Martinus Bastiaans

Matthias Pohlman

Florian Vogt

Wen Xu

Juergen Langewald

Nina Gertrud Bandur

Tiziana Chiodo

Martin Viertelhaus

Franz-Josef Braun

Karsten Körber

Christian Defieber

Koshi Gunjima

Jürgen Langewald

Markus Jegelka

Manfred Ehresmann

Deborah L Culberston

Sebastian Sörgel

Martin John Mclaughlin

Nikolas Huwyler

Johannes Roeckl

Daniel Salinger

Jurgen Langewald

Sebastian Sorgel

Daniel SÄLINGER

Kenichi Kojima

Martinjohn Mclaughlin

The present invention relates to a novel crystalline form of 1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-pyridazin-4-yl-pyrazole-4-carboxamide recently assigned the common name dimpropyridaz. The invention also relates to the use of the crystalline form B for combating invertebrate pests and to formulations for plant protection which contain the crystalline form B of 1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-pyridazin-4-yl-pyrazole-4-carboxamide. The crystalline form B according to the present invention can be identified by powder X-ray diffractometry on the basis of its powder X-ray diffraction diagram, hereinafter also termed powder X-ray diffraction pattern or PXRD pattern, of the polymorph form B recorded using Cu—Kα radiation (1.54178 Å) at 25° C. displays the 3 following reflections, quoted as 2θ values: 20.69±0.10°, 24.15±0.10° and 30.52±0.10°. In addition to these 3 reflections, the polymorph B of the present invention may display in such a PXRD pattern one or more, in particular at least 2, often at least 4, in particular at least 6 or at least 8 reflections and especially all of the reflections quoted hereinafter as 2θ values: 7.99±0.10°, 10.07±0.10°, 12.38±0.10°, 15.31±0.10°, 15.97±0.10°, 16.50±0.10°, 18.03±0.10°, 19.29±0.10°, 20.22±0.0.10°, 20.96±0.10°, 23.40±0.10°, 23.70±0.10°, 26.09±0.10°, 27.26±0.10° and 32.91±0.10°.

Crystalline forms of 1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-pyridazin-4-yl-pyrazole-4-carboxamide

The present invention relates to compounds of formula I, wherein the variables are defined as given in the description and claims. The invention further relates to uses, processes and composition for compounds I.

Bicyclic pesticidal compounds

A method for manufacturing an isocyanate compound represented by formula (2) (2) wherein R1 represents a methyl group, an ethyl group, a cyclopropyl group, a chlorine atom, a bromine atom, or a methoxy group; and R2 represents an alkyl group having 1 to 6 carbon atoms, comprising reacting an aniline compound represented by formula (1) (1) wherein R1 and R2 are defined as above with a phosgene compound at a temperature of from 40&#xb0; C. to the boiling point of the inert solvent in at least one kind of inert solvent.

Manufacturing method for an aromatic isocyanate compound

The invention relates to a process for the preparation of 5-bromo-1,3-dichloro-2-fluoro-benzene by diazotization and reduction of 6-bromo-2,4-dichloro-3-fluoro-aniline, which is obtained by bromination of 2,4-dichloro-3-fluoro-aniline, which is obtained by reduction of 1,3-dichloro-2-fluoro-4-nitro-benzene, and a process for preparing active compounds of formula V (Formula V) wherein the variables are defined in the specification by further transforming 5-bromo-1,3-dichloro-2-fluoro-benzene obtained from 2,4-dichloro-3-fluoro-aniline by the process according to the invention. 

Process for preparation of 5-bromo-1,3-dichloro-2-fluoro-benzene

Provided herein are imino compounds of formula I and stereoisomers, tautomers and salts thereof. Further provided herein are agricultural and veterinary compositions including the compounds. Also provided herein are methods related to the use of these compounds, and the stereoisomers, tautomers and/or salts thereof, for combating invertebrate pests. Further provided herein are methods for combating invertebrate pests, wherein the methods include applying such compounds, steroisomers, tautomers, and salts.

Imino compounds with a 2-chloropyrimidin-5-yl substituent as pest-control agents

The present invention relates to a catalytic process for preparing pyrazoles of formula V comprising the step of cyclizing hydrazone substituted &#x3b1;,&#x3b2;-unsaturated carbonyl compounds by reacting them with hydrogen in a reaction mixture comprising as components (a) a hydrogenation catalyst, (b) an acid selected from Br&#xf8;nsted acids, ammonium salts of Br&#xf8;nsted acids, and Lewis acids, (c) a protic solvent, and optionally (d) an aprotic solvent. 

Catalytic hydrogenation process for preparing pyrazoles

The present invention relates to a process for preparing benzylic amides of formula I wherein the variables have the meaning as defined in the description, by reductive amidation of a nitrile of formula II wherein the variables have the meanings given for formula I, with an activated carbonyl compound of formula III, and which nitrile is obtained by reaction of a compound of formula IV with a halogen compound of formula V, wherein X is a halogen atom, preferably bromo, which halogen compound V in turn is obtained by Sandmeyer reaction of an aniline derivative of formula VI novel compounds of formula I, and processes for preparing compounds of formula XII wherein the variables have the meaning as defined in the description by condensing compounds of formula I with compounds of formula X and subjecting the resulting &#x3b1;,&#x3b2;-unsaturated ketone of formula XI to a reaction with hydroxylamine to yield compounds of formula XII.

Process for preparation of benzylic amides

The present invention relates to a process for the purification of pyrazolpyridazines of formula I wherein the variables are as defined in the specification, by adding HCl to a solution of the pyrazolpyridazine in an inert solvent under non-aqueous conditions, effecting crystallization of the HCl-salt, isolating the resulting precipitate.

Process for purification of pyrazolpyridazines

Compounds of formula I a process for preparation of compounds of formula I; precursor compounds of formula II a process for preparation of precursor compounds of formula II; compounds of formula III a process for the preparation of compounds of formula IV from compounds of formula III and the use of compounds of formula I for the preparation of compounds of formula IV.

Oxy-cope rearrangement for the manufacture of insecticidal cyclopentene compounds

The present invention relates to a process for preparing a pyrazole compound of formula V, which comprises cyclizing a hydrazone substituted &#x3b1;,&#x3b2;-unsaturated carbonyl compound of formula IV by reacting it with a suitable reagent, e.g. a reducing agent, an organometallic reagent or a nucleophilic reagent. The compounds of formula V are versatile reaction tools for the preparation of pyrazole derived fine chemicals. The present invention also relates to pyrazole compounds of formulae Va, Vb, Vc, and VI.

Process for preparing pyrazoles

Described herein is a method for controlling pests of a maize plant, including the step of contacting the maize plant, parts of the maize plant, or its propagation material with components of the ginkgo tree selected from bilobalide, ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J, ginkgolide M, and mixtures thereof. Further described herein is the use of the components of the ginkgo tree for controlling pests on the maize plant, parts of the maize plant, or its plant propagation material.

Control of pests in maize by ginkgolides and bilobalide

The present invention relates to a process for preparing a pyrazole compound of formula V, the process including cyclizing a hydrazone substituted &#x3b1;,&#x3b2;-unsaturated carbonyl compound of formula IV by reacting it with a suitable reagent, e.g. a reducing agent, an organometallic reagent or a nucleophilic reagent. The compounds of formula V are versatile reaction tools for the preparation of pyrazole derived fine chemicals. The present invention also relates to pyrazole compounds of formulae Va, Vb, Vc, and VI.

The present invention relates to novel pyrazoles of formula I. Moreover, the invention relates to processes and intermediates for preparing the pyrazoles of formula I, and also to active compound combinations comprising them, to compositions comprising them, and to their use for protecting growing plants from attack or infestation by invertebrate pests. Furthermore, the invention relates to methods of applying such compounds. The present invention also relates to seed comprising such compounds.

Pyrazoles for controlling invertebrate pests

The present invention relates to N-acylimino compound of formula (I): wherein X is O or S, in particular O; The invention also relates to the use of the N-acylimino heterocyclic compounds, their stereoisomers, their tautomers and their salts, for combating invertebrate pests. Furthermore the invention relates also to methods of combating invertebrate pests, which comprises applying such compounds.

N-acylimino heterocyclic compounds

The present invention relates to pesticidal mixtures comprising as active compounds  The present invention also relates to novel pyrazole compounds of the formula I. The present invention also relates to methods and use of these mixtures and novel compounds for combating invertebrate pests such as insects, arachnids or nematodes in and on plants, and for protecting such plants being infested with pests, especially also for protecting plant propagation material as like seeds.

Pyrazole compound and pesticidal mixtures comprising a pyrazole compound

Growing community of inventors

Ludwigshafen, Germany

Birgit Gockel