Novartis Ag

Novartis Pharma Gmbh

Birgit Bollbuck

Wolfgang Miltz

Till Roehn

Christian Markert

Achim Schlapbach

Philipp Janser

Nikolaus Johannes Stiefl

Jean Quancard

Richard Heng

Lászlo Révész

Daniela Angst

Jorg Eder

Rudolf Wälchli

René Hersperger

Jörg Eder

Laszio Revesz

Alastair DenholmMritain

Rudolf Wálchi

Alastair Novartis Horsham Research Ctre Denholm

The present invention describes novel heteroaryl butanoic acid derivatives that are good drug candidates especially with regard to leukotriene A4 hydrolase (LTA4H). The present invention also relates to pharmaceutical compositions comprising said novel heteroaryl butanoic acid derivatives, methods of using said compounds in the treatment of various diseases and disorders, and processes for preparing the said novel compounds.

Heteroaryl butanoic acid derivatives

The present invention relates to substituted aryl-benzylamine compounds, to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Aryl benzylamine compounds

A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases. 

1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives

A compound of formula I or a pharmaceutically acceptable salt, ester or prodrug thereof wherein the variables have the meanings as defined in the specification. Further disclosed are a method of inhibiting IKK activity using a compound of formula I, a method of inhibiting production of TNF using a compound of formula I, a compound of formula I for use as a pharmaceutical, a pharmaceutical composition comprising a compound of formula I, and use of a compound of formula I in the manufacture of a medicament for use as an immunosuppressant or anti-inflammatory agent. 

2-aminopyrimidine derivatives and their medical use

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Weil am Rhein, Germany

Birgit Bollbuck