Battelle Memorial Institute

Biran H Clowers

Richard Dale Smith

Yehia M Ibrahim

Mikhail E Belov

David C Prior

An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of &#x2dc;1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of &#x2dc;10,000,000 elementary charges, 4) ion ejection time of 40 to 200 &#x3bc;s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.

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West Richland, WA, United States of America

Biran H Clowers